Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy.
作者信息
Gupta Jyoti, Naegele Janice R
机构信息
Department of Neuroscience, Yale School of Medicine.
Department of Biology, Wesleyan University.
出版信息
Epilepsy Curr. 2023 Jun 21;23(4):268-270. doi: 10.1177/15357597231175010. eCollection 2023 Jul-Aug.
Abstract
摘要
相似文献
1
Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy.
Epilepsy Curr. 2023 Jun 21;23(4):268-270. doi: 10.1177/15357597231175010. eCollection 2023 Jul-Aug.
2
Axonal sprouting of GABAergic interneurons in temporal lobe epilepsy.
Epilepsy Behav. 2005 Nov;7(3):390-400. doi: 10.1016/j.yebeh.2005.07.019. Epub 2005 Sep 27.
3
Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy.
Neurobiol Dis. 2022 Nov;174:105879. doi: 10.1016/j.nbd.2022.105879. Epub 2022 Sep 29.
4
Neuroregenerative gene therapy to treat temporal lobe epilepsy in a rat model.
Prog Neurobiol. 2022 Jan;208:102198. doi: 10.1016/j.pneurobio.2021.102198. Epub 2021 Nov 28.
5
Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy.
J Neurosci. 2012 Jan 4;32(1):46-61. doi: 10.1523/JNEUROSCI.2683-11.2012.
6
Alterations of hippocampal GAbaergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Hippocampus. 2001;11(4):452-68. doi: 10.1002/hipo.1060.
7
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
J Neurosci. 2006 Apr 26;26(17):4613-23. doi: 10.1523/JNEUROSCI.0064-06.2006.
8
Enhanced synaptic excitation-inhibition ratio in hippocampal interneurons of rats with temporal lobe epilepsy.
Eur J Neurosci. 2007 Jan;25(2):519-28. doi: 10.1111/j.1460-9568.2006.05296.x.
9
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy.
Cell Stem Cell. 2021 Dec 2;28(12):2104-2121.e10. doi: 10.1016/j.stem.2021.09.002. Epub 2021 Sep 29.
10
Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy.
Exp Neurol. 2021 Aug;342:113724. doi: 10.1016/j.expneurol.2021.113724. Epub 2021 Apr 26.
引用本文的文献
1
Stem cell repair strategies for epilepsy.
Neural Regen Res. 2026 Apr 1;21(4):1428-1446. doi: 10.4103/NRR.NRR-D-24-01337. Epub 2025 Jun 19.
本文引用的文献
1
Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition.
Neuron. 2023 Mar 15;111(6):807-823.e7. doi: 10.1016/j.neuron.2022.12.014. Epub 2023 Jan 9.
2
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy.
NPJ Regen Med. 2022 Aug 1;7(1):38. doi: 10.1038/s41536-022-00234-7.
3
Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy.
Neurosurg Focus. 2020 Apr 1;48(4):E18. doi: 10.3171/2020.2.FOCUS19955.
4
Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells.
Mol Ther Methods Clin Dev. 2019 Apr 8;13:414-430. doi: 10.1016/j.omtm.2019.04.002. eCollection 2019 Jun 14.
5
Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy.
eNeuro. 2019 May 1;6(2). doi: 10.1523/ENEURO.0110-18.2019. Print 2019 Mar/Apr.
6
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):287-296. doi: 10.1073/pnas.1814185115. Epub 2018 Dec 17.
7
Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain.
Stem Cell Res. 2018 Dec;33:83-94. doi: 10.1016/j.scr.2018.10.007. Epub 2018 Oct 5.
8
Hippocampal GABAergic Inhibitory Interneurons.
Physiol Rev. 2017 Oct 1;97(4):1619-1747. doi: 10.1152/physrev.00007.2017.
9
Seizures and epilepsy: an overview for neuroscientists.
Cold Spring Harb Perspect Med. 2015 Jun 1;5(6):a022426. doi: 10.1101/cshperspect.a022426.
10
hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice.
Cell Stem Cell. 2014 Nov 6;15(5):559-73. doi: 10.1016/j.stem.2014.10.006.
Zotero 插件