猴痘感染患者的住院风险——倾向评分匹配分析
Hospitalization risk among patients with Mpox infection-a propensity score matched analysis.
作者信息
Henao-Martínez Andrés F, Orkin Chloe M, Titanji Boghuma K, Rodriguez-Morales Alfonso J, Salinas Jorge L, Franco-Paredes Carlos, Tuells Jose, Chastain Daniel B
机构信息
University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.
SHARE Collaborative, Queen Mary University of London, London, UK.
出版信息
Ther Adv Infect Dis. 2023 Aug 30;10:20499361231196683. doi: 10.1177/20499361231196683. eCollection 2023 Jan-Dec.
BACKGROUND
Monkeypox (Mpox) is a reemerging, neglected viral disease. By May 2023, worldwide Mpox cases surpassed 87,000. Predictive factors for hospitalization with Mpox are lacking.
OBJECTIVE
We aim to compare clinical characteristics and outcomes in hospitalized and nonhospitalized patients with Mpox infection.
DESIGN
A multicenter retrospective case-control cohort of patients with Mpox infection.
METHODS
We performed a propensity score match analysis from a global health network (TrinetX). We compare clinical characteristics and outcomes between hospitalized and nonhospitalized patients with Mpox.
RESULTS
Of 1477 patients, 6% were hospitalized, 52% required an ED visit, and 29% received treatment at urgent care. After propensity score matching, 80 patients remained in each group. Hospitalizations were more common among Black persons (51% 33%, = 0.01), people with HIV (50% 20%, < 0.0001), and those with proctitis (44% 12.5%, < 0.001).
CONCLUSION
Independent predictive factors of hospitalization in our cohort for Mpox included people who are Black with a diagnosis of HIV, severe proctitis, pain requiring opioids, and elevated lactate dehydrogenase. Greater recognition of factors associated with increased risk of Mpox severity and hospitalization is paramount.
背景
猴痘是一种再度出现的被忽视的病毒性疾病。截至2023年5月，全球猴痘病例超过87000例。目前缺乏猴痘住院治疗的预测因素。
目的
我们旨在比较猴痘感染住院患者和非住院患者的临床特征及结局。
设计
一项关于猴痘感染患者的多中心回顾性病例对照队列研究。
方法
我们从一个全球健康网络（TrinetX）进行了倾向评分匹配分析。我们比较了猴痘住院患者和非住院患者的临床特征及结局。
结果
在1477例患者中，6%住院治疗，52%需要到急诊就诊，29%在紧急护理机构接受治疗。经过倾向评分匹配后，每组各有80例患者。住院治疗在黑人（51%对33%，P = 0.01）、艾滋病毒感染者（50%对20%，P < 0.0001）以及患有直肠炎的患者（44%对12.5%，P < 0.001）中更为常见。
结论
在我们的猴痘队列中，住院治疗的独立预测因素包括被诊断为艾滋病毒感染的黑人、严重直肠炎、需要使用阿片类药物止痛以及乳酸脱氢酶升高的患者。更深入认识与猴痘严重程度和住院风险增加相关的因素至关重要。
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