Yang Shuangling, Yang Hongzhi, Zhang Yaxing
School of Health Sciences, Guangzhou Xinhua University, Guangzhou, Guangdong, China.
Department of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Front Pharmacol. 2023 Aug 16;14:1194026. doi: 10.3389/fphar.2023.1194026. eCollection 2023.
Type 2 diabetes mellitus, nonalcoholic fatty liver disease (NAFLD), cardio-cerebrovascular diseases (CCVDs), hyperuricemia and gout, and metabolic-related sexual dysfunction are metabolic diseases that affect human health in modern society. Scientists have made great efforts to investigate metabolic diseases using cell models or animal models in the past. However, the findings from cells or animals are difficult to translate into clinical applications due to factors such as the and differences; the differences in anatomy, physiology, and genetics between humans and animals; and the differences in microbiome-host interaction. The Chinese have extensively used the medicated diet of traditional Chinese medicine (TCM) (also named as Yao-Shan of TCM, Chinese Yao-Shan et al.) to maintain or improve cardiometabolic health for more than 2,200 years. These ancient classic diets of TCM are essential summaries of long-term life and clinical practices. Over the past 5 years, our group has made every effort to collect and sort out the classic Yao-Shan of TCM from the ancient TCM literature since , especially these are involved in the prevention and treatment of metabolic diseases, such as diabetes, NAFLD, CCVDs, hyperuricemia and gout, and sexual dysfunction. Here, we summarized and discussed the classic Yao-Shan of TCM for metabolic diseases according to the time recorded in the ancient literature, and revised the Latin names of the raw materials in these Yao-Shan of TCM. Moreover, the modern medicine evidences of some Yao-Shan of TCM on metabolic diseases have also been summarized and emphasized in here. However, the exact composition (in terms of ratios), preparation process, and dosage of many Yao-Shan are not standardized, and their main active ingredients are vague. Uncovering the mystery of Yao-Shan of TCM through modern biological and chemical strategies will help us open a door, which is ancient but now looks new, to modulate metabolic homeostasis and diseases.
2型糖尿病、非酒精性脂肪性肝病（NAFLD）、心脑血管疾病（CCVDs）、高尿酸血症和痛风以及代谢相关性功能障碍是影响现代社会人类健康的代谢性疾病。过去，科学家们致力于使用细胞模型或动物模型来研究代谢性疾病。然而，由于种属差异、人类与动物在解剖学、生理学和遗传学上的差异以及微生物群与宿主相互作用的差异等因素，细胞或动物实验的结果很难转化为临床应用。中国人广泛使用中药食疗（也称为中医药膳、中国药膳等）来维持或改善心脏代谢健康已有2200多年的历史。这些古老的中医经典食疗是长期生活和临床实践的重要总结。在过去的5年里，我们团队竭尽全力从古中医文献中收集和整理经典的中医药膳，尤其是那些涉及糖尿病、NAFLD、CCVDs、高尿酸血症和痛风以及性功能障碍等代谢性疾病防治的药膳。在此，我们根据古代文献记载的时间对治疗代谢性疾病的经典中医药膳进行了总结和讨论，并修订了这些中医药膳中原材料的拉丁名称。此外，这里还总结并强调了一些中医药膳对代谢性疾病的现代医学证据。然而，许多中医药膳的确切成分（比例）、制备工艺和剂量尚未标准化，其主要活性成分也不明确。通过现代生物学和化学策略揭开中医药膳的奥秘，将有助于我们打开一扇通往调节代谢稳态和疾病的古老而崭新的大门。
