Singh Divya, Lawrence Kapil, Singh Sunil, Ercisli Sezai, Choudhary Ravish
Department of Biochemistry and Biochemical Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, India.
United Institute of Pharmacy, U.C.E.R., Prayagraj, India.
Saudi J Biol Sci. 2022 May;29(5):3772-3790. doi: 10.1016/j.sjbs.2022.03.009. Epub 2022 Mar 10.
common name- foxtail, kangni) is one of the major food crops which is prominently cultivated in southern regions of India and in certain regions of Uttar Pradesh. Besides the crop's consumption as a general source of carbohydrate rich cereal, the seeds of the crop are comprised of more fiber. So, it is recommended to add in the dietary supplementation of the diabetic people across the country.
In this paper, it intends to investigate the antidiabetic activity and antioxidant activity of seeds in diabetic rats.
The six genotypes of foxtail millets ( namely Kangni-1, Kangni-4, Kangni-5, Kangni-6, Kangni-7 & Kangni-10 respectively were subjected to in vitro investigations via. comprehensive metabolic panel (CMP) involving blood glucose study, Kidney & Liver function test, and antioxidant study ( and were performed in vivo animal investigations in Wistar rats. The STZ induced diabetic rats were fed with doses of different S. italica seed aqueous extract to evaluate its anti-hyperglycemic activity by oral administration of SISAE. Further, it was compared with Glibenclamide which acts as one of the standard oral hypoglycemic agents.
From achieved outcomes, a significant fall of blood glucose level (70%) produced 300 mg SISAE/kg b.w. after 6 h of extract administration. However, no change could be produced by these doses of the SISAE in normal rats' blood glucose levels. A significant fall in glucose level along with significant glycemic control by lower HbA1c levels was observed in diabetic treated rats after 3 weeks of treatment with 300 mg of SISAE/kg b.w./day when comparing to untreated diabetic rats. Among these five genotypes of , the differences in the glycemic index were found. a significant fall could be found in blood glucose levels of Wistar rats, when every experimental rat was incorporating with the extract of different genotypes of than the rats treated with Glibenclamide in every 7 days of interval. The level of catalase, SOD, GST, GPx, GSH and TBARS showed variation while the rats were fed with the extract of in the liver test of rats. In kidney function test, the result shows that there is significant relationship between foxtail extract and kidney function of STZ induced diabetes rats. They show the change in their serum creatinine level, serum urea and serum uric acid.
The result obtained from the study shows that the extract of seeds is capable for the hypolipidemic and antihyperglycemic activities, thereby, they serve as one of the good sources for herbal medicinal items.
黍（俗称狐尾粟、康尼）是印度南部和北方邦某些地区主要种植的粮食作物之一。除了作为富含碳水化合物谷物的常见食用作物外，该作物种子含有更多纤维。因此，建议将其纳入全国糖尿病患者的膳食补充剂中。
本文旨在研究黍种子对糖尿病大鼠的降血糖活性和抗氧化活性。
对六种黍基因型（分别为康尼 -1、康尼 -4、康尼 -5、康尼 -6、康尼 -7 和康尼 -10）通过综合代谢指标（CMP）进行体外研究，包括血糖研究、肝肾功测试和抗氧化研究，并在Wistar大鼠中进行体内动物实验。用链脲佐菌素诱导糖尿病大鼠，喂食不同剂量的意大利黍种子水提取物，通过口服该提取物评估其降血糖活性。此外，将其与作为标准口服降糖药之一的格列本脲进行比较。
从实验结果来看，给予300mg/kg体重的意大利黍种子水提取物6小时后，血糖水平显著下降（70%）。然而，这些剂量的提取物对正常大鼠的血糖水平没有影响。与未治疗的糖尿病大鼠相比，用300mg/kg体重/天的意大利黍种子水提取物治疗3周后的糖尿病大鼠，血糖水平显著下降，糖化血红蛋白水平降低，血糖得到有效控制。在这五种黍基因型中，发现了血糖指数的差异。每隔7天，当每只实验大鼠摄入不同基因型黍提取物时，其血糖水平的下降幅度比用格列本脲治疗的大鼠更大。在大鼠肝脏测试中，当大鼠喂食黍提取物时，过氧化氢酶、超氧化物歧化酶、谷胱甘肽 -S-转移酶、谷胱甘肽过氧化物酶、还原型谷胱甘肽和丙二醛水平出现变化。在肾功能测试中，结果表明黍提取物与链脲佐菌素诱导的糖尿病大鼠的肾功能之间存在显著关系。它们的血清肌酐水平、血清尿素和血清尿酸出现了变化。
研究结果表明，黍种子提取物具有降血脂和降血糖活性，因此，它们可作为草药的优质来源之一。
