Al-Ghamdi Ahmed M, Alfalah Seba, Anwer Khurshid, Alzaher Ibrahim, Alsuhaimi Ahmed A, Aldhafeeri Sahar M
Department of General and Plastic Surgery, Dammam Medical Complex (DMC/EC), Kingdom of Saudi Arabia.
Ann Med Surg (Lond). 2023 Jul 31;85(9):4638-4642. doi: 10.1097/MS9.0000000000001102. eCollection 2023 Sep.
Condyloma acuminatum (CA) or genital warts, represents a rare sexually transmitted disease caused by the human papillomavirus. Infection occurs when host basal cells are exposed to viral infection through a damaged epithelial barrier, during sexual intercourse, or due to other minor skin abrasions. Giant condyloma acuminatum (GCA) has a higher rate of malignant transformation than CA.
We are presenting a 44-year-old single gentleman known as a smoker, hepatitis B positive, vitiligo, and hypercholesteromia. He was an alcoholic and had multiple heterosexual relationships abroad. Referred from the dermatology clinic, complaining of genital warts that had increased in size for 10 years.
CA management includes local applications like imiquimod and podophyllotoxin and clinician-administered treatments such as cryotherapy, surgical excision, electrosurgery, and CO laser therapy. Other options, such as interferon, radiotherapy, or chemotherapy, are available. The selection of therapy should be individualized and based upon consideration of the extent of the disease, patient preference, cost, adverse effects, treatment availability, and the response to previous treatments. Complete surgical excision is the treatment of choice for GCA.
We present a patient with GCA in the perianal area that was surgically treated with an excellent outcome.
尖锐湿疣(CA)或生殖器疣,是一种由人乳头瘤病毒引起的罕见性传播疾病。当宿主基底细胞在性交过程中通过受损的上皮屏障暴露于病毒感染时,或由于其他轻微皮肤擦伤而发生感染。巨大尖锐湿疣(GCA)的恶变率高于CA。
我们报告一名44岁的单身男性,有吸烟史,乙肝阳性,患有白癜风和高胆固醇血症。他是一名酗酒者,在国外有多个异性性伴侣。从皮肤科诊所转诊而来,主诉生殖器疣增大已有10年。
CA的治疗包括局部应用咪喹莫特和鬼臼毒素,以及临床医生实施的治疗,如冷冻疗法、手术切除、电外科手术和CO2激光治疗。还有其他选择,如干扰素、放疗或化疗。治疗的选择应个体化,并基于对疾病范围、患者偏好、成本、不良反应、治疗可及性以及对既往治疗的反应的考虑。完全手术切除是GCA的首选治疗方法。
我们报告一例肛周GCA患者,经手术治疗取得了良好效果。