Suppr超能文献

巨大尖锐湿疣的外科治疗:一例病例报告及文献综述

Giant condyloma acuminatum surgical management: a case report and literature review.

作者信息

Al-Ghamdi Ahmed M, Alfalah Seba, Anwer Khurshid, Alzaher Ibrahim, Alsuhaimi Ahmed A, Aldhafeeri Sahar M

机构信息

Department of General and Plastic Surgery, Dammam Medical Complex (DMC/EC), Kingdom of Saudi Arabia.

出版信息

Ann Med Surg (Lond). 2023 Jul 31;85(9):4638-4642. doi: 10.1097/MS9.0000000000001102. eCollection 2023 Sep.

Abstract

INTRODUCTION AND IMPORTANCE

Condyloma acuminatum (CA) or genital warts, represents a rare sexually transmitted disease caused by the human papillomavirus. Infection occurs when host basal cells are exposed to viral infection through a damaged epithelial barrier, during sexual intercourse, or due to other minor skin abrasions. Giant condyloma acuminatum (GCA) has a higher rate of malignant transformation than CA.

CASE PRESENTATION

We are presenting a 44-year-old single gentleman known as a smoker, hepatitis B positive, vitiligo, and hypercholesteromia. He was an alcoholic and had multiple heterosexual relationships abroad. Referred from the dermatology clinic, complaining of genital warts that had increased in size for 10 years.

CLINICAL DISCUSSION

CA management includes local applications like imiquimod and podophyllotoxin and clinician-administered treatments such as cryotherapy, surgical excision, electrosurgery, and CO laser therapy. Other options, such as interferon, radiotherapy, or chemotherapy, are available. The selection of therapy should be individualized and based upon consideration of the extent of the disease, patient preference, cost, adverse effects, treatment availability, and the response to previous treatments. Complete surgical excision is the treatment of choice for GCA.

CONCLUSION

We present a patient with GCA in the perianal area that was surgically treated with an excellent outcome.

摘要

引言与重要性

尖锐湿疣(CA)或生殖器疣,是一种由人乳头瘤病毒引起的罕见性传播疾病。当宿主基底细胞在性交过程中通过受损的上皮屏障暴露于病毒感染时,或由于其他轻微皮肤擦伤而发生感染。巨大尖锐湿疣(GCA)的恶变率高于CA。

病例介绍

我们报告一名44岁的单身男性,有吸烟史,乙肝阳性,患有白癜风和高胆固醇血症。他是一名酗酒者,在国外有多个异性性伴侣。从皮肤科诊所转诊而来,主诉生殖器疣增大已有10年。

临床讨论

CA的治疗包括局部应用咪喹莫特和鬼臼毒素,以及临床医生实施的治疗,如冷冻疗法、手术切除、电外科手术和CO2激光治疗。还有其他选择,如干扰素、放疗或化疗。治疗的选择应个体化,并基于对疾病范围、患者偏好、成本、不良反应、治疗可及性以及对既往治疗的反应的考虑。完全手术切除是GCA的首选治疗方法。

结论

我们报告一例肛周GCA患者,经手术治疗取得了良好效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8c8/10473329/69a45c22b356/ms9-85-4638-g001.jpg

相似文献

1
Giant condyloma acuminatum surgical management: a case report and literature review.
Ann Med Surg (Lond). 2023 Jul 31;85(9):4638-4642. doi: 10.1097/MS9.0000000000001102. eCollection 2023 Sep.
4
Giant perianal condyloma acuminatum: Reconstruction with bilateral gluteal fasciocutaneous V-Y advancement flap.
Ulus Cerrahi Derg. 2015 Jul 2;31(3):170-3. doi: 10.5152/UCD.2015.2838. eCollection 2015.
5
Anal condyloma acuminatum.
Gastroenterol Nurs. 2009 Sep-Oct;32(5):342-9. doi: 10.1097/SGA.0b013e3181b85d4e.
7
A perianal conundrum and its management: Condyloma versus carcinoma.
Int J Surg Case Rep. 2023 Feb;103:107864. doi: 10.1016/j.ijscr.2022.107864. Epub 2022 Dec 31.
8
Recalcitrant extragenital giant condyloma acuminatum: A need for combination therapy.
Dermatol Ther. 2019 May;32(3):e12867. doi: 10.1111/dth.12867. Epub 2019 Mar 18.
9
Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review.
J Gastrointest Cancer. 2022 Dec;53(4):1083-1092. doi: 10.1007/s12029-021-00713-y. Epub 2021 Oct 25.
10
Buschke-Löwenstein tumors: A series of 7 case reports.
Exp Ther Med. 2022 Jun;23(6):393. doi: 10.3892/etm.2022.11320. Epub 2022 Apr 13.

引用本文的文献

1
Buschke-Löwenstein Tumour: Surgical Management and Literature Review of an Unusual Disease.
Cureus. 2025 Jun 9;17(6):e85639. doi: 10.7759/cureus.85639. eCollection 2025 Jun.

本文引用的文献

1
2019 IUSTI-Europe guideline for the management of anogenital warts.
J Eur Acad Dermatol Venereol. 2020 Aug;34(8):1644-1653. doi: 10.1111/jdv.16522.
6
Images in clinical medicine. Giant condyloma acuminatum of Buschke and Löwenstein.
N Engl J Med. 2011 Oct 27;365(17):1624. doi: 10.1056/NEJMicm1006915.
7
Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ.
Tech Coloproctol. 2011 Sep;15(3):313-8. doi: 10.1007/s10151-011-0715-3. Epub 2011 Jul 9.
8
A surgical approach to anogenital Buschke Loewenstein tumours (giant condyloma acuminata).
Acta Chir Belg. 2009 Oct;109(5):612-6. doi: 10.1080/00015458.2009.11680497.
9
Surgical excision of extensive anal condylomata not associated with risk of anal stenosis.
Int J Colorectal Dis. 2008 Sep;23(9):853-6. doi: 10.1007/s00384-008-0494-0. Epub 2008 Jun 12.
10
External beam radiotherapy for extensive genital condyloma acuminate: a role in selected patients?
Clin Oncol (R Coll Radiol). 2008 Feb;20(1):91-2. doi: 10.1016/j.clon.2007.08.016. Epub 2007 Oct 17.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验