Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang.
Int J Hyperthermia. 2013;29(1):17-20. doi: 10.3109/02656736.2012.758874.
Genital warts are more extensive and difficult to treat in patients with diabetes mellitus due to defective immune responses.
Our aim was to confirm the suitability of local hyperthermia for the treatment of genital warts in patients with diabetes mellitus and to investigate the immune cells in lesional areas at different time intervals after treatment.
We treated three diabetic patients with extensive genital warts by local hyperthermia at 44 °C for 30 min a day for 3 consecutive days plus 2 additional days 1 week later, then once a week till there showed signs of clinical clearance. Immunohistochemical profile was described on serial biopsies from a patient with confluent plaques.
The warty lesions in the patients resolved in 6, 4 and 9 weeks, respectively. Immunohistochemical staining in the regressing warts revealed abundant infiltrating CD4+ T and CD8+ T lymphocytes (P < 0.01), as well as macrophages and CD1a+ dendritic cells.
This preliminary study suggested that local hyperthermia was a safe and effective single modality in the treatment of genital warts in diabetic patients and could induce a rapid immune response in lesional skin.
由于免疫反应缺陷，糖尿病患者的生殖器疣更广泛且更难治疗。
我们旨在确认局部热疗治疗糖尿病患者生殖器疣的适宜性，并研究治疗后不同时间病变区域的免疫细胞。
我们对 3 例患有广泛生殖器疣的糖尿病患者采用 44°C 局部热疗，每天 30 分钟，连续 3 天，之后在 1 周后再加 2 天，然后每周 1 次，直到出现临床清除迹象。对 1 例融合斑块患者进行连续活检，描述其免疫组织化学特征。
3 例患者的疣状病变分别在 6、4 和 9 周内消退。消退的疣中免疫组织化学染色显示大量浸润的 CD4+ T 和 CD8+ T 淋巴细胞（P<0.01），以及巨噬细胞和 CD1a+树突状细胞。
这项初步研究表明，局部热疗是治疗糖尿病患者生殖器疣的一种安全有效的单一方法，可在皮损皮肤中诱导快速免疫反应。
