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Buschke-Löwenstein肿瘤：7例病例报告系列

Buschke-Löwenstein tumors: A series of 7 case reports.

作者信息

Boda Daniel, Cutoiu Ana, Bratu Dalia, Bejinariu Nona, Crutescu Rodica

机构信息

Department of Dermatology, 'Ponderas' Academic Hospital, 014142 Bucharest, Romania.

Department of Dermatology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

出版信息

Exp Ther Med. 2022 Jun;23(6):393. doi: 10.3892/etm.2022.11320. Epub 2022 Apr 13.

DOI:10.3892/etm.2022.11320
PMID:35495587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9047027/
Abstract

Giant condyloma acuminatum (GCA), or Buschke-Löwenstein tumor (BLT), represents an infrequent sexually transmitted disease (STD), caused by human papillomavirus (HPV), especially genotype 6 or 11. There are numerous risk factors for HPV, such as multiple sexual partners, homosexuality, prostitution, chronic genital infections, as well as the lack of proper hygiene. HPV infection is a field infection, where large areas of cells at a tissue surface are affected by the HPV virus; therefore, once the GCA is excised, treatment of the whole affected genital area needs to be undertaken. The treatment is classified into topical therapy (podophyllin, 5-FU, radiotherapy, topical photodynamic therapy), excisional therapy (CO laser, cryotherapy, electrotherapy, surgery) and immunotherapy (imiquimod). However, the 'gold standard' therapy is represented by wide surgical excision without grafting, since it is considered that healing is an improved approach, because there is no risk of recurrences on fibrotic tissue. A total of 7 cases of the BLT with comorbidities and particularities are presented and it is recommended that it be taken into consideration that the incidence of the disease is increasing, emphasizing the importance of an early diagnosis, as well as an adequate treatment.

摘要

巨大尖锐湿疣（GCA），又称Buschke-Löwenstein瘤（BLT），是一种由人乳头瘤病毒（HPV），特别是6型或11型引起的罕见性传播疾病（STD）。HPV有许多危险因素，如多个性伴侣、同性恋、卖淫、慢性生殖器感染以及缺乏适当的卫生条件。HPV感染是一种灶性感染，组织表面的大片细胞会受到HPV病毒的影响；因此，一旦切除GCA，就需要对整个受影响的生殖器区域进行治疗。治疗方法分为局部治疗（鬼臼毒素、5-氟尿嘧啶、放射治疗、局部光动力疗法）、切除治疗（CO2激光、冷冻疗法、电疗法、手术）和免疫治疗（咪喹莫特）。然而，“金标准”治疗是以不植皮的广泛手术切除为代表，因为人们认为这种愈合方式更好，因为纤维化组织没有复发风险。本文介绍了7例合并症和特殊情况的BLT病例，并建议考虑到该疾病的发病率正在上升，强调早期诊断以及充分治疗的重要性。

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