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代谢手术在老年日本患者中的安全性和有效性。

Safety and effectiveness of metabolic surgery in older Japanese patients.

作者信息

Takemoto Minoru, Hayashi Aiko, Inaba Yosuke, Tanaka Tomohiro, Chun Tae-Hwa, Hayashi Hideki, Kasama Kazunori, Saiki Atsuhito, Sasaki Akira, Okazumi Shinichi, Matsubara Hisahiro, Tatsuno Ichiro

机构信息

Department of Diabetes, Metabolism, and Endocrinology International University of Health and Welfare Narita Japan.

International University of Health and Welfare Narita Hospital Narita Japan.

出版信息

Ann Gastroenterol Surg. 2023 May 22;7(5):750-756. doi: 10.1002/ags3.12680. eCollection 2023 Sep.

Abstract

AIM

According to the current guidelines in Japan, the upper age limit for bariatric and metabolic surgery is 65 y. This study aimed to examine the appropriateness of this upper age limit.

METHODS

Using the database maintained by the Japanese Society for Treatment of Obesity, we conducted an analysis of patients in two age groups: those aged <65 y and those aged ≥65 y. Our analysis focused on postoperative weight loss, improvement in comorbidities, and frequency of perioperative complications.

RESULTS

A total of 2885 patients aged <65 y (mean, 43.9 ± 9.5 y) with a preoperative body mass index of 42.4 ± 8.1 kg/m, while 56 aged ≥65 y (mean, 67.3 ± 3.2 y; maximum, 78 y) with a preoperative body mass index of 40.5 ± 6.6 kg/m. Patients aged ≥65 y had a higher rate of dyslipidemia and hypertension. The rates of reoperation, surgical complications, and postoperative complications did not differ between the age groups. Both groups achieved significant weight loss postoperatively, and no differences in the improvement of comorbidities were noted. After adjusting the covariate balance via propensity score matching, no age-related differences in perioperative and postoperative complications were observed.

CONCLUSION

Metabolic surgery is safe and effective for older patients with clinically severe obesity. Weight loss was less in patients aged ≥65 y, but the percentage of total weight loss did not differ between the groups.

摘要

目的

根据日本目前的指南,肥胖症和代谢手术的年龄上限为65岁。本研究旨在探讨这一年龄上限的合理性。

方法

利用日本肥胖治疗学会维护的数据库,我们对两个年龄组的患者进行了分析:年龄<65岁的患者和年龄≥65岁的患者。我们的分析重点是术后体重减轻、合并症的改善情况以及围手术期并发症的发生率。

结果

共有2885例年龄<65岁(平均43.9±9.5岁)的患者,术前体重指数为42.4±8.1kg/m²,而56例年龄≥65岁(平均67.3±3.2岁;最大78岁)的患者,术前体重指数为40.5±6.6kg/m²。年龄≥65岁的患者血脂异常和高血压的发生率较高。年龄组之间再次手术率、手术并发症和术后并发症发生率没有差异。两组术后均实现了显著的体重减轻,合并症改善情况也无差异。通过倾向评分匹配调整协变量平衡后,未观察到围手术期和术后并发症存在年龄相关差异。

结论

代谢手术对临床严重肥胖的老年患者是安全有效的。年龄≥65岁的患者体重减轻较少,但两组总体体重减轻的百分比没有差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef72/10472352/12162da4dae7/AGS3-7-750-g001.jpg

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