Zhang Xusheng, Chen Bendong
Ningxia Medical University, Yinchuan, China.
General Hospital of Ningxia Medical University, Yinchuan, China.
Front Oncol. 2023 Aug 18;13:1206043. doi: 10.3389/fonc.2023.1206043. eCollection 2023.
Cancer secondary to dermatomyositis (DM) is defined as paraneoplastic dermatomyositis, which is one of the major subtypes of DM. However, cases of DM with intrahepatic cholangiocarcinoma (ICC) are rarely reported. In the course of our clinical work, we encountered a case of a middle-aged female patient who was diagnosed with DM for 7 years and then diagnosed with ICC, and we would like to share this case. In addition, in order to further investigate the deeper mechanism of ICC associated with DM, we also analyzed the dataset related to DM and ICC in the Gene Expression Omnibus (GEO) database based on the machine learning methods and found that poly(ADP-ribose) polymerase family member 12 (PARP12) and metallothionein 1M (MT1M) were closely associated with ICC secondary to DM. They are potentially important biomarkers for predicting the occurrence of ICC in patients with DM.
继发于皮肌炎（DM）的癌症被定义为副肿瘤性皮肌炎，它是DM的主要亚型之一。然而，DM合并肝内胆管癌（ICC）的病例鲜有报道。在我们的临床工作过程中，我们遇到了一例中年女性患者，她被诊断为DM 7年后又被诊断出患有ICC，我们想分享这个病例。此外，为了进一步探究ICC与DM相关的深层机制，我们还基于机器学习方法分析了基因表达综合数据库（GEO）中与DM和ICC相关的数据集，发现聚（ADP-核糖）聚合酶家族成员12（PARP12）和金属硫蛋白1M（MT1M）与继发于DM的ICC密切相关。它们可能是预测DM患者发生ICC的重要生物标志物。
