丝氨酸相关的一碳代谢重编程：一种新的抗癌治疗策略。
Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy.
作者信息
Zhang Jing, Bai Jian, Gong Chen, Wang Jianhua, Cheng Yi, Zhao Jing, Xiong Huihua
机构信息
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Front Oncol. 2023 Aug 18;13:1184626. doi: 10.3389/fonc.2023.1184626. eCollection 2023.
Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more serine for proliferation. The cancer-related genes that are involved in serine metabolism also show changes corresponding to metabolic alterations. Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies.
肿瘤代谢是癌症研究的主要焦点，而代谢重编程是恶性肿瘤的一个重要特征。丝氨酸是一种重要的非必需氨基酸，是肿瘤中一碳单位的主要来源。癌细胞比正常细胞增殖更多，增殖需要更多的丝氨酸。参与丝氨酸代谢的癌症相关基因也表现出与代谢改变相对应的变化。在此，我们综述了丝氨酸相关的一碳代谢及其作为抗肿瘤治疗策略靶点的潜力。
Zotero 插件