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全球纳米技术在肝癌中的应用研究趋势与热点：文献计量学与可视化分析（2000 - 2022年）

Research trends and hot spots in global nanotechnology applications in liver cancer: a bibliometric and visual analysis (2000-2022).

作者信息

Jin Xi, Zhao Jingwei, Li Hongshuang, Zheng Mengting, Shao Jiao, Chen Zhanguo

机构信息

Department of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

出版信息

Front Oncol. 2023 Jul 28;13:1192597. doi: 10.3389/fonc.2023.1192597. eCollection 2023.

DOI:10.3389/fonc.2023.1192597
PMID:37664074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10472833/
Abstract

BACKGROUND

Liver cancer (LC) is one of the most common malignancies. Currently, nanotechnology has made great progress in LC research, and many studies on LC nanotechnology have been published. This study aims to discuss the current status, hot spots, and research trends in this field through bibliometric analysis.

METHODS

The Web of Science Core Collection (WoSCC) database was searched for papers related to hepatocellular carcinoma (HCC) included from January 2000 to November 2022, and its research hotspots and trends were visualized and analyzed with the help of VOSviewer. In addition, a search was conducted to find LC papers related to nanotechnology. Then we used the visual analysis software VOSviewer and CiteSpace to evaluate the contributions of countries/regions, authors, and journals related to the topic and analyze keywords to understand the research priorities and hot spots in the field as well as the development direction.

RESULTS

There are 1908 papers in the highly cited literature on LC, and its research hotspots are pathogenesis, risk factors, and survival rate. The literature on the application of nanotechnology in LC had 921 papers. Among them, China (n=560, 60.8%) and the United States (n=170, 18.5%) were the countries with the highest number of published papers. Wang Yan (n=11) and Llovet JM (n=131) were the first authors and co-cited authors, respectively. The International Journal of Nanomedicine was the most prolific academic journal (n=41). In addition to "hepatocellular carcinoma" and "nanoparticles", the most frequent keyword was "drug delivery". In recent years, "metastasis" and "diagnosis" appeared in the keyword bursts. This indicates that the application of nanoparticles in the early diagnosis and drug delivery of LC (including liver metastasis) has a good prospect.

CONCLUSION

Nanotechnology has received more and more attention in the medical field in recent years. As nanoparticles are easily localized in organelles and cells, they can increase drug permeability in tumor tissues, improve drug delivery efficiency and reduce drug toxicity. Our research results were the first scientific evaluation of the application of nanotechnology in LC, providing scholars with research hotspots and development trends.

摘要

背景

肝癌是最常见的恶性肿瘤之一。目前，纳米技术在肝癌研究中取得了很大进展，并且已经发表了许多关于肝癌纳米技术的研究。本研究旨在通过文献计量分析探讨该领域的现状、热点和研究趋势。

方法

在科学网核心合集（WoSCC）数据库中检索2000年1月至2022年11月收录的与肝细胞癌（HCC）相关的论文，并借助VOSviewer对其研究热点和趋势进行可视化分析。此外，进行检索以查找与纳米技术相关的肝癌论文。然后我们使用可视化分析软件VOSviewer和CiteSpace来评估与该主题相关的国家/地区、作者和期刊的贡献，并分析关键词以了解该领域的研究重点和热点以及发展方向。

结果

肝癌高被引文献中有1908篇论文，其研究热点是发病机制、危险因素和生存率。纳米技术在肝癌中应用的文献有921篇。其中，中国（n = 560，60.8%）和美国（n = 170，18.5%）是发表论文数量最多的国家。第一作者为王燕（n = 11），共被引作者为洛弗特·J·M（n = 131）。《国际纳米医学杂志》是发文量最多的学术期刊（n = 41）。除了“肝细胞癌”和“纳米颗粒”外，最频繁出现的关键词是“药物递送”。近年来，“转移”和“诊断”出现在关键词爆发中。这表明纳米颗粒在肝癌（包括肝转移）的早期诊断和药物递送中的应用具有良好前景。

结论

近年来，纳米技术在医学领域受到越来越多的关注。由于纳米颗粒易于定位于细胞器和细胞中，它们可以增加药物在肿瘤组织中的渗透性，提高药物递送效率并降低药物毒性。我们的研究结果是对纳米技术在肝癌中应用的首次科学评估，为学者们提供了研究热点和发展趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/2bc08647018b/fonc-13-1192597-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/864091bedf28/fonc-13-1192597-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/aea4f6fe5a43/fonc-13-1192597-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/2bc08647018b/fonc-13-1192597-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/032632543d2b/fonc-13-1192597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/28cb7bc7ee8c/fonc-13-1192597-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/74340c38fedd/fonc-13-1192597-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/068d56c2d302/fonc-13-1192597-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/59a17df0c9f2/fonc-13-1192597-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/864091bedf28/fonc-13-1192597-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/aea4f6fe5a43/fonc-13-1192597-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c06c/10472833/2bc08647018b/fonc-13-1192597-g008.jpg

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