Department of Gastroenterology, Creighton University - St. Joseph's Hospital and Medical Center Phoenix, AZ 85013, United States.
Department of Internal Medicine, Creighton University St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, United States.
World J Gastroenterol. 2023 Aug 21;29(31):4736-4743. doi: 10.3748/wjg.v29.i31.4736.
Diabetes is a highly prevalent disease that was initially simplified into three major types: Type 1, type 2 and gestational diabetes. With the global rise in incidence of acute pancreatitis (AP), a lesser-known type of diabetes referred to as diabetes of the exocrine pancreas (DEP) is becoming more recognized. However, there is a poor understanding of the inherent relationship between diabetes and AP. There is established data about certain diseases affecting the exocrine function of the pancreas which can lead to diabetes. More specifically, there are well established guidelines for diagnosis and management of DEP caused be chronic pancreatitis. Conversely, the sequelae of AP leading to diabetes has limited recognition and data. The purpose of this review is to provide a comprehensive summary of the prevalence, epidemiology, pathophysiology and future research aims of AP-related diabetes. In addition, we propose a screening and diagnostic algorithm to aid clinicians in providing better care for their patients.
糖尿病是一种高发疾病,最初被简化为三种主要类型:1 型、2 型和妊娠糖尿病。随着全球急性胰腺炎 (AP)发病率的上升,一种鲜为人知的糖尿病,即胰腺外分泌腺糖尿病 (DEP),越来越受到人们的认识。然而,人们对糖尿病和 AP 之间的内在关系知之甚少。关于某些影响胰腺外分泌功能的疾病会导致糖尿病,已经有了确凿的数据。更具体地说,对于由慢性胰腺炎引起的 DEP,已经有了明确的诊断和管理指南。相反,AP 导致糖尿病的后遗症认识和数据有限。本综述的目的是全面总结 AP 相关糖尿病的患病率、流行病学、病理生理学和未来研究目标。此外,我们提出了一种筛选和诊断算法,以帮助临床医生为患者提供更好的护理。