Pike Madeline R, Engel Melissa L, Lipner Emily, Hammen Constance, Brennan Patricia A
Department of Psychology, Temple University, 1701 N 13th St, Philadelphia, PA, 19122, USA.
Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA, 30322, USA.
Child Psychiatry Hum Dev. 2025 Jun;56(3):740-750. doi: 10.1007/s10578-023-01600-2. Epub 2023 Sep 4.
Prenatal maternal stress (PNMS) is linked to physical sequelae in offspring, including childhood asthma. This study sought to examine the roles of objective and subjective PNMS in the development of asthma at offspring ages 5 and 15. The sample included 815 mother-child dyads from the Mater Misericordiae Mothers' Hospital-University of Queensland Study of Pregnancy. PNMS was measured via retrospective self-report during pregnancy and 3-5 days after birth. Postnatal maternal stress was measured at offspring age 5. Objective PNMS was associated with elevated asthma risk at age 5 (OR 1.21, 95% CI 1.00, 1.45, p = 0.05), albeit not above concurrent postnatal stress. Sex moderated the association between PNMS and asthma at age 15, controlling for postnatal stress. Sex stratified analyses revealed a positive association between objective PNMS and age 15 asthma in females, but not males. Results provide evidence that PNMS may impact asthma outcomes in adolescence.
产前母亲压力（PNMS）与后代的身体后遗症有关，包括儿童哮喘。本研究旨在探讨客观和主观PNMS在后代5岁和15岁时哮喘发展中的作用。样本包括来自仁慈圣母医院 - 昆士兰大学孕期研究的815对母婴。PNMS通过孕期及产后3 - 5天的回顾性自我报告进行测量。产后母亲压力在后代5岁时进行测量。客观PNMS与5岁时哮喘风险升高相关（OR 1.21，95% CI 1.00，1.45，p = 0.05），尽管未高于同时期的产后压力。在控制产后压力的情况下，性别调节了15岁时PNMS与哮喘之间的关联。性别分层分析显示，客观PNMS与15岁女性哮喘呈正相关，而与男性无关。结果提供了证据表明PNMS可能影响青少年的哮喘结局。
