Liu Zhengguo, You Xue-Yi
Tianjin Engineering Center of Urban River Eco-purification Technology, School of Environmental Science and Engineering, Tianjin University, Jinnan District, Tianjin 300350, China.
Tianjin Engineering Center of Urban River Eco-purification Technology, School of Environmental Science and Engineering, Tianjin University, Jinnan District, Tianjin 300350, China.
Sci Total Environ. 2023 Dec 10;903:166766. doi: 10.1016/j.scitotenv.2023.166766. Epub 2023 Sep 2.
Microplastics are widely distributed in the environment, including the atmosphere, soil and water bodies. They have been found to have toxic effects on organisms. The impact on human health is also receiving considerable attention. Microplastics can be found in drinking water, food, air and plastic products, and they can enter human body through the pathways such as ingestion, inhalation, and skin contact. After exposure to microplastics, they can induce cellular toxicity and produce toxic effects on multiple organs and systems, including the digestive, respiratory, nervous, reproductive and cardiovascular systems. This paper presents a comprehensive review and analysis on the recent progress of human exposure studies, in vitro experiments, rodent experiments, and other model experiments in microplastic human toxicity research. It comprehensively analyzes the potential human toxic effects of microplastics, providing a theoretical basis for further research on microplastic human toxicity and its mechanisms. Furthermore, this paper highlights the knowledge gaps and provides the recommendations for future research on human toxicity of microplastics.
微塑料广泛分布于环境中，包括大气、土壤和水体。已发现它们对生物体具有毒性作用。其对人类健康的影响也受到了相当多的关注。微塑料存在于饮用水、食物、空气和塑料制品中，并且它们可以通过摄入、吸入和皮肤接触等途径进入人体。接触微塑料后，它们可诱导细胞毒性，并对包括消化、呼吸、神经、生殖和心血管系统在内的多个器官和系统产生毒性作用。本文对微塑料人体毒性研究中人体暴露研究、体外实验、啮齿动物实验及其他模型实验的最新进展进行了全面综述和分析。它全面分析了微塑料对人体的潜在毒性作用，为进一步研究微塑料人体毒性及其机制提供了理论依据。此外，本文突出了知识空白，并为未来微塑料人体毒性研究提供了建议。
