KU Leuven, Leuven Brain Institute, Department of Biology, Animal Physiology and Neurobiology Division, Neural Circuit Development & Regeneration research group, Naamsestraat 61, 3000 Leuven, Belgium.
KU Leuven, Leuven Brain Institute, Department of Biology, Animal Physiology and Neurobiology Division, Cellular Communication & Neurodegeneration research group, Naamsestraat 61, 3000 Leuven, Belgium.
Ageing Res Rev. 2023 Nov;91:102065. doi: 10.1016/j.arr.2023.102065. Epub 2023 Sep 3.
Thanks to medical and technological improvements, our world population has become ever-greying. In consequence, the incidence and prevalence of age-related central nervous system neuropathies, such as Alzheimer's (AD) and Parkinson's disease (PD), are increasing tremendously. Despite many research efforts, the precise aetiology of these age-related neurodegenerative disorders remains elusive, highlighting the urgent need for more effective treatments. Current preclinical research mainly uses animal models that do not fully recapitulate the complex cellular context in which these diseases occur, thereby lacking good construct validity. Indeed, most investigations are performed using relatively young animals, thereby ignoring the ageing environment in which neurodegenerative diseases manifest. This points out a major hiatus in current research: a vertebrate model organism that combines the complex disease context (onset, spreading and further manifestation into functional impairment) with an ageing environment. In recent years, the African turquoise killifish has emerged as a promising novel animal model to study age-related neurodegenerative disorders that combines these essential features. In this review, we bundle all reported findings up till now and provide a detailed overview of the neurodegenerative events within the central nervous system of this teleost fish, with a focus on PD.
由于医学和技术的进步，我们的世界人口变得越来越老龄化。因此，与年龄相关的中枢神经系统神经病变的发病率和流行率，如阿尔茨海默病（AD）和帕金森病（PD），正在急剧增加。尽管进行了许多研究努力，但这些与年龄相关的神经退行性疾病的确切病因仍然难以捉摸，这凸显了急需更有效的治疗方法。目前的临床前研究主要使用不能完全重现这些疾病发生的复杂细胞环境的动物模型，因此缺乏良好的结构有效性。事实上，大多数研究都是使用相对年轻的动物进行的，从而忽略了神经退行性疾病表现出来的老化环境。这指出了当前研究中的一个主要缺陷：一种结合了复杂疾病背景（发病、传播和进一步表现为功能障碍）和老化环境的脊椎动物模式生物。近年来，非洲蓝鲷鱼已成为一种很有前途的新型动物模型，可用于研究与年龄相关的神经退行性疾病，该模型结合了这些重要特征。在这篇综述中，我们汇集了迄今为止所有的报告发现，并详细概述了这种硬骨鱼中枢神经系统中的神经退行性事件，重点是 PD。
