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类固醇性青光眼:一种可避免的致盲原因。

Steroid-induced glaucoma: an avoidable cause of irreversible blindness.

机构信息

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

出版信息

BMJ Case Rep. 2023 Sep 4;16(9):e254709. doi: 10.1136/bcr-2023-254709.

DOI:10.1136/bcr-2023-254709
PMID:37666571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10481737/
Abstract

A man in his 70s on regular follow-up with an ophthalmologist for 10 years presented with blurry vision in his right eye for 4 days. He was diagnosed with elevated intraocular pressure (IOP) bilaterally 18 months earlier and treated with antiglaucoma eye-drops. On direct questioning, he admitted to using fixed combination tobramycin 0.3%/dexamethasone 0.1% eye-drops frequently to relieve ocular redness and discomfort in both eyes for 3.5 years without his ophthalmologist's knowledge. Examination disclosed markedly elevated IOP, advanced optic disc cupping and tunnel vision due to steroid-induced glaucoma bilaterally. After cessation of the eye-drops and 2 weeks of antiglaucoma therapy, his IOP returned to normal and his visual field remained stable for 4 years.Our case highlights the danger of habitual self-treatment of prescription medications containing corticosteroids and the importance of taking a detailed medication history in the diagnosis and management of steroid-induced glaucoma.

摘要

一位 70 多岁的男性,10 年来定期接受眼科医生的随访,因右眼视力模糊 4 天就诊。18 个月前他被诊断为双侧眼压升高,并接受了抗青光眼眼药水治疗。经直接询问,他承认在未经眼科医生同意的情况下,3.5 年来经常使用固定剂量的妥布霉素 0.3%/地塞米松 0.1%眼药水来缓解双眼的眼红和不适。检查发现双侧眼压明显升高,视盘凹陷和隧道视野,这是由于类固醇引起的青光眼。停止使用眼药水并接受 2 周的抗青光眼治疗后,他的眼压恢复正常,视野在 4 年内保持稳定。我们的病例强调了习惯性自行使用含有皮质类固醇的处方药物的危险,以及在诊断和管理类固醇性青光眼时详细询问用药史的重要性。

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本文引用的文献

1
Ophthalmology Self-medication Practices: A Questionnaire-based Study.眼科自我药疗实践:一项基于问卷调查的研究。
Ophthalmic Epidemiol. 2021 Oct;28(5):453-457. doi: 10.1080/09286586.2020.1869272. Epub 2020 Dec 28.
2
Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management.类固醇性青光眼:流行病学、病理生理学和临床管理。
Surv Ophthalmol. 2020 Jul-Aug;65(4):458-472. doi: 10.1016/j.survophthal.2020.01.002. Epub 2020 Feb 11.
3
Commentary: Blindness from glaucoma associated with steroid abuse in children.评论:儿童因滥用类固醇导致青光眼失明。
Indian J Ophthalmol. 2019 Oct;67(10):1655-1656. doi: 10.4103/ijo.IJO_946_19.
4
Pattern of steroid misuse in vernal keratoconjunctivitis resulting in steroid induced glaucoma and visual disability in Indian rural population: An important public health problem in pediatric age group.春季角结膜炎患者中类固醇使用不当导致的类固醇诱导性青光眼和视力障碍在印度农村人群中的模式:儿科年龄段的一个重要公共卫生问题。
Indian J Ophthalmol. 2019 Oct;67(10):1650-1655. doi: 10.4103/ijo.IJO_2143_18.
5
Steroid-induced glaucoma and blindness in vernal keratoconjunctivitis.春季角结膜炎导致的皮质类固醇性青光眼和盲。
Br J Ophthalmol. 2020 Feb;104(2):265-269. doi: 10.1136/bjophthalmol-2019-313988. Epub 2019 May 4.
6
Monitoring long-term oral corticosteroids.长期口服皮质类固醇监测。
BMJ Open Qual. 2017 Nov 8;6(2):e000209. doi: 10.1136/bmjoq-2017-000209. eCollection 2017.
7
Steroid-induced Glaucoma: An Avoidable Irreversible Blindness.类固醇性青光眼:一种可避免的不可逆性失明。
J Curr Glaucoma Pract. 2017 May-Aug;11(2):67-72. doi: 10.5005/jp-journals-l0028-1226. Epub 2017 Aug 5.
8
Current Approach in the Diagnosis and Management of Uveitic Glaucoma.葡萄膜炎性青光眼的诊断与治疗现状
Biomed Res Int. 2015;2015:742792. doi: 10.1155/2015/742792. Epub 2015 Oct 19.
9
The Cost-Effectiveness Analysis of Teleglaucoma Screening Device.远程青光眼筛查设备的成本效益分析
PLoS One. 2015 Sep 18;10(9):e0137913. doi: 10.1371/journal.pone.0137913. eCollection 2015.
10
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Ophthalmic Epidemiol. 2012 Aug;19(4):236-41. doi: 10.3109/09286586.2012.689076.