Shen Junyi, Ouyang Zhi, Zhong Jian, Long Yicen, Sun Yujia, Zeng Ye
Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Aug 25;40(4):625-631. doi: 10.7507/1001-5515.202211011.
Organoids are three-dimensional structures formed by self-organizing growth of cells , which own many structures and functions similar with those of corresponding organs. Although the organoid culture technologies are rapidly developed and the original cells are abundant, the organoid cultured by current technologies are rather different with the real organs, which limits their application. The major challenges of organoid cultures are the immature tissue structure and restricted growth, both of which are caused by poor functional vasculature. Therefore, how to develop the vascularization of organoids has become an urgent problem. We presently reviewed the progresses on the original cells of organoids and the current methods to develop organoids vascularization, which provide clues to solve the above-mentioned problems.
类器官是由细胞自组织生长形成的三维结构，具有许多与相应器官相似的结构和功能。尽管类器官培养技术迅速发展且原始细胞丰富，但目前技术培养的类器官与真实器官仍有很大差异，这限制了它们的应用。类器官培养的主要挑战是组织结构不成熟和生长受限，这两者都是由功能不良的脉管系统导致的。因此，如何实现类器官的血管化已成为一个紧迫的问题。我们目前综述了类器官原始细胞的研究进展以及当前实现类器官血管化的方法，为解决上述问题提供线索。
