[特发性肺纤维化中上皮-间质转化的生物力学特性]
[Biomechanical properties of epithelial mesenchymal transition in idiopathic pulmonary fibrosis].
作者信息
Li Mingyan, Sun Meihao, Jia Yuanbo, Ren Hui, Liu Han
机构信息
Henan University of Chinese Medicine, Academy of Chinese Medicine Sciences, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan & Ministry of Education of PR China, Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450016, P.R. China.
Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Xi'an 710049, P.R. China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Aug 25;40(4):632-637. doi: 10.7507/1001-5515.202206016.
Idiopathic pulmonary fibrosis (IPF) is a progressive scar-forming disease with a high mortality rate that has received widespread attention. Epithelial mesenchymal transition (EMT) is an important part of the pulmonary fibrosis process, and changes in the biomechanical properties of lung tissue have an important impact on it. In this paper, we summarize the changes in the biomechanical microenvironment of lung tissue in IPF-EMT in recent years, and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonary fibrosis on the process of EMT, the effects of mechanical factors on the behavior of alveolar epithelial cells in EMT and the biomechanical signaling in EMT, in order to provide new references for the research on the prevention and treatment of IPF.
特发性肺纤维化（IPF）是一种具有高死亡率的进行性瘢痕形成疾病，已受到广泛关注。上皮-间质转化（EMT）是肺纤维化过程的重要组成部分，肺组织生物力学特性的变化对其有重要影响。本文总结了近年来IPF-EMT中肺组织生物力学微环境的变化，并对肺纤维化中机械微环境改变对EMT进程的影响、机械因素对EMT中肺泡上皮细胞行为的影响以及EMT中的生物力学信号进行了系统综述，以期为IPF的防治研究提供新的参考。
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