海藻酸钠微球的制备及应用进展
[Progress in preparation and application of sodium alginate microspheres].
作者信息
Liu Xuanyu, Wang Yuhui, Liang Ziwei, Lian Xiaojie, Huang Di, Hu Yinchun, Wei Yan
机构信息
Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.
Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Aug 25;40(4):792-798. doi: 10.7507/1001-5515.202211048.
Sodium alginate (SA) is a kind of natural polymer material extracted from kelp, which has excellent biocompatibility, non-toxicity, biodegradability and abundant storage capacity. The formation condition of sodium alginate gel is mild, effectively avoiding the inactivation of active substances. After a variety of preparation methods, sodium alginate microspheres are widely used in the fields of biomaterials and tissue engineering. This paper reviewed the common methods of preparing alginate microspheres, including extrusion, emulsification, electrostatic spraying, spray drying and coaxial airflow, and discussed their applications in biomedical fields such as bone repair, hemostasis and drug delivery.
海藻酸钠（SA）是一种从海带中提取的天然高分子材料，具有优异的生物相容性、无毒、可生物降解性和丰富的储存能力。海藻酸钠凝胶的形成条件温和，有效避免了活性物质的失活。经过多种制备方法后，海藻酸钠微球在生物材料和组织工程领域得到了广泛应用。本文综述了海藻酸钠微球的常见制备方法，包括挤压法、乳化法、静电喷涂法、喷雾干燥法和同轴气流法，并讨论了它们在骨修复、止血和药物递送等生物医学领域的应用。
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