Zhang Zhenyu, Chen Minnan, Zhan Wenjing, Chen Yuechun, Wang Tongtong, Chen Zhonghua, Fu Yifei, Zhao Gang, Mao Dong, Ruan Jingjing, Yuan Feng-Lai
Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China.
Nantong First People's Hospital, Nantong, 226001, China.
Cell Death Discov. 2023 Sep 4;9(1):330. doi: 10.1038/s41420-023-01624-6.
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.
酸敏感离子通道1a（ASIC1a）是酸敏感离子通道（ASIC）超家族的重要成员，可被细胞外质子激活，在人体中广泛表达，包括神经系统和外周组织。通过ASIC1a激活导致的钙离子过度积累可能发生在血液或局部组织的酸化微环境中。ASIC1a介导的钙诱导凋亡与多种病理状态有关，包括神经疾病、癌症和类风湿性关节炎。本综述总结了ASIC1a在不同疾病状态下通过各种信号通路调节细胞凋亡中的作用，为未来关于潜在机制的研究和治疗策略的开发提供见解。
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