乞丐的盛宴：肿瘤免疫微环境中的代谢与癌症治疗。
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy.
机构信息
Departments of Surgery and Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Graduate Programs in Immunology and Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Cell Metab. 2023 Jul 11;35(7):1101-1113. doi: 10.1016/j.cmet.2023.06.003. Epub 2023 Jun 29.
Abstract
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we review immune-related functions of core metabolic pathways, key metabolites, and crucial nutrient transporters in the TME, discuss their metabolic, signaling, and epigenetic impact on tumor immunity and immunotherapy, and explore how these insights can be applied to the development of more effective modalities to potentiate the function of T cells and sensitize tumor cell receptivity to immune attack, thereby overcoming therapeutic resistance.
摘要
肿瘤微环境（TME）中的代谢编程改变了荷瘤小鼠和癌症患者的肿瘤免疫和免疫治疗反应。在这里，我们综述了 TME 中核心代谢途径、关键代谢物和重要营养转运蛋白的免疫相关功能，讨论了它们对肿瘤免疫和免疫治疗的代谢、信号和表观遗传影响，并探讨了如何将这些见解应用于开发更有效的方式来增强 T 细胞的功能和提高肿瘤细胞对免疫攻击的敏感性，从而克服治疗抵抗。
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本文引用的文献
1
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Nat Metab. 2023 Feb;5(2):314-330. doi: 10.1038/s42255-022-00730-6. Epub 2023 Jan 30.
2
Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.免疫和致癌代谢途径的交汇导致免疫治疗期间癌症的超进展。
Cancer Cell. 2023 Feb 13;41(2):304-322.e7. doi: 10.1016/j.ccell.2022.12.008. Epub 2023 Jan 12.
3
Immunoediting instructs tumor metabolic reprogramming to support immune evasion.免疫编辑指导肿瘤代谢重编程以支持免疫逃逸。
Cell Metab. 2023 Jan 3;35(1):118-133.e7. doi: 10.1016/j.cmet.2022.12.003.
4
Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth.髓系细胞衍生的衣康酸抑制细胞毒性 CD8 T 细胞并促进肿瘤生长。
Nat Metab. 2022 Dec;4(12):1660-1673. doi: 10.1038/s42255-022-00676-9. Epub 2022 Nov 14.
5
Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function.代谢物 d-2HG 改变 T 细胞代谢，从而损害 CD8+T 细胞的功能。
Science. 2022 Sep 30;377(6614):1519-1529. doi: 10.1126/science.abj5104. Epub 2022 Sep 29.
6
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity.乳酸增加 CD8+T 细胞的干性以增强抗肿瘤免疫。
Nat Commun. 2022 Sep 6;13(1):4981. doi: 10.1038/s41467-022-32521-8.
7
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Cell Metab. 2022 Aug 2;34(8):1137-1150.e6. doi: 10.1016/j.cmet.2022.06.008. Epub 2022 Jul 11.
9
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Nature. 2022 Jul;607(7917):135-141. doi: 10.1038/s41586-022-04849-0. Epub 2022 Jun 22.
10
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J Immunother Cancer. 2022 Jun;10(6). doi: 10.1136/jitc-2021-004378.
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