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T cells require mitochondria to proliferate, function and generate memory.
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Research trends on lactate in cancer: a bibliometric analysis and comprehensive review (2015-2024).
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Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness.
Nat Metab. 2023 Feb;5(2):314-330. doi: 10.1038/s42255-022-00730-6. Epub 2023 Jan 30.
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Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.
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Immunoediting instructs tumor metabolic reprogramming to support immune evasion.
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Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth.
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Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function.
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Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity.
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8 T cells.
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cBAF complex components and MYC cooperate early in CD8 T cell fate.
Nature. 2022 Jul;607(7917):135-141. doi: 10.1038/s41586-022-04849-0. Epub 2022 Jun 22.

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