Departments of Surgery and Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Graduate Programs in Immunology and Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cell Metab. 2023 Jul 11;35(7):1101-1113. doi: 10.1016/j.cmet.2023.06.003. Epub 2023 Jun 29.
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we review immune-related functions of core metabolic pathways, key metabolites, and crucial nutrient transporters in the TME, discuss their metabolic, signaling, and epigenetic impact on tumor immunity and immunotherapy, and explore how these insights can be applied to the development of more effective modalities to potentiate the function of T cells and sensitize tumor cell receptivity to immune attack, thereby overcoming therapeutic resistance.
肿瘤微环境(TME)中的代谢编程改变了荷瘤小鼠和癌症患者的肿瘤免疫和免疫治疗反应。在这里,我们综述了 TME 中核心代谢途径、关键代谢物和重要营养转运蛋白的免疫相关功能,讨论了它们对肿瘤免疫和免疫治疗的代谢、信号和表观遗传影响,并探讨了如何将这些见解应用于开发更有效的方式来增强 T 细胞的功能和提高肿瘤细胞对免疫攻击的敏感性,从而克服治疗抵抗。