Metabolic Disease Management Center of Endocrinology Department, Tianjin 4th Central Hospital, The 4th Center Clinical College of Tianjin Medical University, No.1 Zhongshan Road, Tianjin, 300140, China.
NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, 300134, China.
Sci Rep. 2023 Sep 4;13(1):14579. doi: 10.1038/s41598-023-41883-y.
Non-targeted metabonomic techniques were used to explore changes in metabolic profiles of patients with early onset and late onset T2DM. Newly diagnosed early onset T2DM (EarT2DM) and late onset T2DM (LatT2DM) patients were recruited, and the matched age, sex, and low-risk population of diabetes mellitus were selected as the control group. 117 adults were recruited in the study, including 21 in EarT2DM group with 25 in corresponding control group (heaCG1), and 48 in LatT2DM group with 23 in corresponding control group (heaCG2). There were 15 relatively distinctive metabolic variants in EarT2DM group and 10 distinctive metabolic variants in LatT2DM group. The same changing pathways mainly involved protein, aminoacyl-tRNA biosynthesis, fatty acid biosynthesis, taurine metabolism, arginine biosynthesis, lysosome and mTOR signaling pathway. The independent disturbed pathways in EarT2DM included branched chain amino acids, alanine, aspartate and glutamate metabolism. The independent disturbed pathways in LatT2DM involved linoleic acid metabolism, biosynthesis of unsaturated fatty acids, arginine, proline metabolism and FoxO signaling pathway. T2DM patients at different diagnosed ages may have different metabolite profiles. These metabolic differences need to be further verified.
采用非靶向代谢组学技术探索早发和晚发 2 型糖尿病患者代谢谱的变化。招募了新诊断的早发 2 型糖尿病（EarT2DM）和晚发 2 型糖尿病（LatT2DM）患者，并选择年龄、性别和糖尿病低风险人群作为对照组。本研究共纳入 117 名成年人，其中 EarT2DM 组 21 例，相应对照组（heaCG1）25 例，LatT2DM 组 48 例，相应对照组（heaCG2）23 例。EarT2DM 组有 15 个相对独特的代谢变异，LatT2DM 组有 10 个独特的代谢变异。相同的变化途径主要涉及蛋白质、氨酰-tRNA 生物合成、脂肪酸生物合成、牛磺酸代谢、精氨酸生物合成、溶酶体和 mTOR 信号通路。EarT2DM 中独立受干扰的途径包括支链氨基酸、丙氨酸、天冬氨酸和谷氨酸代谢。LatT2DM 中受干扰的独立途径涉及亚油酸代谢、不饱和脂肪酸的生物合成、精氨酸、脯氨酸代谢和 FoxO 信号通路。不同诊断年龄的 T2DM 患者可能有不同的代谢物谱。这些代谢差异需要进一步验证。
