Polonsky William H, Soriano Emily C
Behavioral Diabetes Institute, San Diego, CA, USA.
University of California, San Diego, San Diego, CA, USA.
J Diabetes Sci Technol. 2025 May;19(3):758-768. doi: 10.1177/19322968231198533. Epub 2023 Sep 4.
Continuous subcutaneous insulin infusion (CSII) use in adults with type 1 diabetes offers psychosocial and clinical benefits, but little is known about its impact on such outcomes in the type 2 diabetes (T2D) population. To address this gap, we conducted a quasi-experimental prospective study to assess psychosocial, glycemic, and behavioral changes over six months in T2D adults on multiple daily injections (MDI) who were interested in starting Omnipod DASH, comparing those who did versus did not start on it.
In total, 458 adults with T2D completed baseline questionnaires assessing psychosocial dimensions (eg, diabetes distress), clinical metrics (eg, HbA [glycosylated hemoglobin]), and behavioral measures (eg, missed mealtime boluses). Six months later, 220 (48.0%) completed the same questionnaire again. To examine differences in outcomes over time between those who began CSII (n = 176) versus those who remained on MDI (n = 44), a latent change score approach was used.
The CSII users reported greater gains than MDI users on all major psychosocial metrics, including overall well-being ( < .001) diabetes distress ( < .001), perceived T2D impact on quality of life ( = .003), and hypoglycemic worries and concerns ( < .001). The CSII users similarly reported a larger decline in HbA than MDI users ( < .05) and greater declines in two critical self-care behaviors: number of missed mealtime boluses ( < .001) and number of days of perceived overeating ( = .001).
The introduction of CSII (Omnipod DASH) in T2D adults can contribute to significant psychosocial, glycemic, and behavioral benefits, indicating that broader use of CSII in the T2D population may be of value.
在1型糖尿病成人患者中使用持续皮下胰岛素输注(CSII)具有心理社会和临床益处,但对于其对2型糖尿病(T2D)人群这些结局的影响知之甚少。为填补这一空白,我们进行了一项准实验性前瞻性研究,以评估有兴趣开始使用Omnipod DASH的接受多次每日注射(MDI)的T2D成人在六个月内的心理社会、血糖和行为变化,比较开始使用与未开始使用的患者。
共有458名T2D成人完成了基线问卷调查,评估心理社会维度(如糖尿病困扰)、临床指标(如糖化血红蛋白[HbA])和行为指标(如错过餐时大剂量胰岛素注射次数)。六个月后,220名(48.0%)患者再次完成相同问卷。为检验开始使用CSII的患者(n = 176)与继续使用MDI的患者(n = 44)在不同时间结局的差异,采用了潜在变化分数法。
在所有主要心理社会指标上,CSII使用者比MDI使用者有更大改善,包括总体幸福感(P <.001)、糖尿病困扰(P <.001)、T2D对生活质量的感知影响(P =.003)以及低血糖担忧(P <.001)。CSII使用者同样报告HbA下降幅度比MDI使用者更大(P <.05),在两项关键自我护理行为上下降幅度更大:错过餐时大剂量胰岛素注射次数(P <.001)和感觉暴饮暴食天数(P =.001)。
在T2D成人中引入CSII(Omnipod DASH)可带来显著的心理社会、血糖和行为益处,表明在T2D人群中更广泛使用CSII可能具有价值。