Gao Yonghong, Wang Yan, Zhang Dandan, Wu Tingting, Li Qingwei
Department of Cardiology, Shanghai Jinshan District Tinglin Hospital, Shanghai, 201505, People's Republic of China.
Department of General Practice, Shanghai Jinshan District Tinglin Hospital, Shanghai, 201505, People's Republic of China.
J Multidiscip Healthc. 2023 Aug 30;16:2543-2556. doi: 10.2147/JMDH.S423558. eCollection 2023.
In the general population of the United States (U.S.), the relationship between dietary inflammatory index (DII) and mortality (all-cause, cardiovascular disease (CVD)-related, and cancer-related) is still unclear. Therefore, in this research, we examined the association of DII with mortality caused by all-cause, CVD-related, and cancer-related causes.
Data from the National Health and Nutrition Examination Survey (NHANES) from 1999-2018 was used for exploring the link between DII and all-cause, CVD-related, and cancer-related mortality through the use of Cox proportional hazard models and restricted cubic spline model. In addition, subgroup analyses were further performed.
The study included 29,013 individuals from the NHANES from 1999 to 2018. The DII scores were nominated as low (T1: -5.281-0.724), medium (T2: 0.725-2.513), and high-grade inflammation (T3: 2.514-5.795), with T1 serving as the reference group. The linear positive correlation between DII and all-cause and CVD-related mortality was studied using Cox regression analysis. In the full-adjusted model, as compared with the individuals with T1 DII scores, adjusted odds ratios with 95% confidence intervals for all-cause and CVD-related mortality were 1.149 (1.059, 1.247), and 1.186 (1.084, 1.297), as well as 1.197 (1.032, 1.387), and 1.198 (1.019, 1.409), respectively. However, there was no statistical significance between DII and cancer-related mortality. The RCS plot also showed a significant increase in all-cause and CVD-related mortality with increased DII. Nevertheless, as DII scores increased, cancer-related mortality first increased and then decreased.
All-cause and CVD-related mortality are linked independently to high DII scores, independently. Further study of the association of DII scores with mortality caused by all-cause, CVD-related, and cancer-related causes is necessary to explore.
在美国普通人群中，饮食炎症指数（DII）与死亡率（全因死亡率、心血管疾病（CVD）相关死亡率和癌症相关死亡率）之间的关系仍不明确。因此，在本研究中，我们研究了DII与全因、CVD相关和癌症相关原因导致的死亡率之间的关联。
使用1999 - 2018年美国国家健康与营养检查调查（NHANES）的数据，通过Cox比例风险模型和受限立方样条模型探索DII与全因、CVD相关和癌症相关死亡率之间的联系。此外，还进一步进行了亚组分析。
该研究纳入了1999年至2018年NHANES的29,013名个体。DII得分被分为低（T1：-5.281 - 0.724）、中（T2：0.725 - 2.513）和高等级炎症（T3：2.514 - 5.795），以T1作为参照组。使用Cox回归分析研究DII与全因和CVD相关死亡率之间的线性正相关。在完全调整模型中，与T1 DII得分的个体相比，全因和CVD相关死亡率的调整后比值比及其95%置信区间分别为1.149（1.059，1.247）和1.186（1.084，1.297），以及1.197（1.032，1.387）和1.198（1.019，1.409）。然而，DII与癌症相关死亡率之间无统计学意义。RCS图还显示，随着DII升高，全因和CVD相关死亡率显著增加。尽管如此，随着DII得分增加，癌症相关死亡率先升高后降低。
全因和CVD相关死亡率分别独立地与高DII得分相关。有必要进一步研究DII得分与全因、CVD相关和癌症相关原因导致的死亡率之间的关联。
