Department of Cardiology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230000, Anhui, China.
Department of Emergency, First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei, 230000, Anhui, China.
Sci Rep. 2024 Oct 14;14(1):23998. doi: 10.1038/s41598-024-75381-6.
Diet and inflammation are crucial in the incidence and progression of coronary heart disease (CHD). This study aimed to investigate the correlation between the Dietary inflammatory index (DII) and all-cause mortality in CHD patients. A total of 1,303 CHD patients from the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2018 were included. Multivariate Cox regression was used to explore the correlation between the DII and the risk of all-cause mortality in these patients. Restricted cubic spline (RCS) analysis was also utilized to examine the relationship between the DII and all-cause mortality risk in CHD patients. Additionally, subgroup analyses were conducted to determine how the correlation between the DII and all-cause mortality varied across different demographics. During a median follow-up period of 77 months among 1,303 CHD patients, 536 died from all causes. The DII scores were significantly higher in deceased patients compared to survivors. After adjusting for confounding factors, the multivariate Cox regression analysis indicated a strong positive correlation between the DII and all-cause mortality in CHD patients. RCS analysis suggested a non-linear relationship between the DII and all-cause mortality among CHD patients. Additionally, an increase in DII was more pronounced in its impact on female patients. The DII is strongly correlated with the risk of all-cause mortality among CHD patients, particularly among females. Thus, managing dietary inflammation is vital for the prevention and treatment of CHD, especially in female patients.
饮食与炎症在冠心病(CHD)的发生和发展中起着至关重要的作用。本研究旨在探讨饮食炎症指数(DII)与 CHD 患者全因死亡率之间的相关性。本研究共纳入了 2003 年至 2018 年期间来自国家健康和营养调查(NHANES)的 1303 名 CHD 患者。采用多变量 Cox 回归分析探讨 DII 与这些患者全因死亡率风险之间的相关性。还利用限制性三次样条(RCS)分析来检验 DII 与 CHD 患者全因死亡率风险之间的关系。此外,进行了亚组分析,以确定 DII 与全因死亡率之间的相关性在不同人群中的变化情况。在 1303 名 CHD 患者的中位随访期为 77 个月期间,有 536 人死于各种原因。与幸存者相比,死亡患者的 DII 评分明显更高。在调整混杂因素后,多变量 Cox 回归分析表明 DII 与 CHD 患者全因死亡率之间存在强烈的正相关关系。RCS 分析表明 DII 与 CHD 患者全因死亡率之间存在非线性关系。此外,DII 对女性患者的影响更为显著。DII 与 CHD 患者全因死亡率风险密切相关,特别是在女性患者中。因此,管理饮食炎症对于 CHD 的预防和治疗至关重要,尤其是在女性患者中。