Mitsis Andreas, Kyriakou Michaela, Sokratous Stefanos, Karmioti Georgia, Drakomathioulakis Michail, Myrianthefs Michael, Ziakas Antonios, Tzikas Stergios, Kassimis George
Cardiology Department, Nicosia General Hospital, Nicosia 2029, Cyprus.
First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Biomedicines. 2024 Mar 21;12(3):701. doi: 10.3390/biomedicines12030701.
The role of inflammation in the pathophysiology of acute myocardial infarction (AMI) is well established. In recognizing inflammation's pivotal role in AMI, this manuscript systematically traces the historical studies spanning from early attempts to the present landscape. Several anti-inflammatory trials targeting inflammation in post-AMI have been performed, and this review includes the key trials, as well as examines their designs, patient demographics, and primary outcomes. Efficacies and challenges are analyzed, thereby shedding light on the translational implications of trial outcomes. This article also discusses emerging trends, ongoing research, and potential future directions in the field. Practical applications and implications for clinical practice are considered by providing a holistic view of the evolving landscape of anti-inflammatory interventions in the context of AMI.
炎症在急性心肌梗死（AMI）病理生理学中的作用已得到充分证实。在认识到炎症在AMI中的关键作用后，本文系统地追溯了从早期尝试到当前情况的历史研究。已经开展了多项针对AMI后炎症的抗炎试验，本综述纳入了关键试验，并审视了其设计、患者人口统计学特征和主要结局。分析了疗效和挑战，从而阐明试验结果的转化意义。本文还讨论了该领域的新趋势、正在进行的研究以及潜在的未来方向。通过全面审视AMI背景下抗炎干预不断演变的情况，考虑了其在临床实践中的实际应用和意义。
