School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Phytother Res. 2023 Nov;37(11):5159-5192. doi: 10.1002/ptr.7975. Epub 2023 Sep 5.
Flavonoids are natural polyphenolic compounds considered safe, pleiotropic, and readily available molecules. It is widely distributed in various food products such as fruits and vegetables and beverages such as green tea, wine, and coca-based products. Many studies have reported the anticancer potential of flavonoids against different types of cancers, including solid tumors. The chemopreventive effect of flavonoids is attributed to various mechanisms, including modulation of autophagy, induction of cell cycle arrest, apoptosis, and antioxidant defense. Despite of significant anticancer activity of flavonoids, their clinical translation is limited due to their poor biopharmaceutical attributes (such as low aqueous solubility, limited permeability across the biological membranes (intestinal and blood-brain barrier), and stability issue in biological systems). A nanoparticulate system is an approach that is widely utilized to improve the biopharmaceutical performance and therapeutic efficacy of phytopharmaceuticals. The present review discusses the significant anticancer potential of promising flavonoids in different cancers and the utilization of nanoparticulate systems to improve their nanoantioxidant activity further to enhance the anticancer activity of loaded promising flavonoids. Although, various plant-derived secondary metabolites including flavonoids have been recommended for treating cancer, further vigilant research is warranted to prove their translational values.
类黄酮是天然多酚化合物，被认为是安全、多效且易于获得的分子。它广泛分布于各种食品，如水果和蔬菜，以及各种饮料，如绿茶、葡萄酒和以古柯为基础的产品。许多研究报告了类黄酮对不同类型癌症（包括实体瘤）的抗癌潜力。类黄酮的化学预防作用归因于多种机制，包括自噬调节、细胞周期阻滞诱导、细胞凋亡和抗氧化防御。尽管类黄酮具有显著的抗癌活性，但由于其生物制药特性差（如低水溶性、穿过生物膜（肠和血脑屏障）的渗透性有限，以及在生物系统中的稳定性问题），其临床转化受到限制。纳米颗粒系统是一种广泛用于提高植物药生物制药性能和治疗效果的方法。本综述讨论了有前途的类黄酮在不同癌症中的显著抗癌潜力，以及利用纳米颗粒系统进一步提高其纳米抗氧化活性，以增强负载有前途的类黄酮的抗癌活性。尽管包括类黄酮在内的各种植物源性次生代谢物已被推荐用于治疗癌症，但仍需要进一步进行警惕性研究，以证明它们的转化价值。
