School of Pharmacy, Shandong Second Medical University, Weifang 261053, China.
Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang 261053, China.
Molecules. 2024 May 17;29(10):2374. doi: 10.3390/molecules29102374.
The tumor microenvironment (TME) can aid tumor cells in evading surveillance and clearance by immune cells, creating an internal environment conducive to tumor cell growth. Consequently, there is a growing focus on researching anti-tumor immunity through the regulation of immune cells within the TME. Various bioactive compounds in traditional Chinese medicine (TCM) are known to alter the immune balance by modulating the activity of immune cells in the TME. In turn, this enhances the body's immune response, thus promoting the effective elimination of tumor cells. This study aims to consolidate recent findings on the regulatory effects of bioactive compounds from TCM on immune cells within the TME. The bioactive compounds of TCM regulate the TME by modulating macrophages, dendritic cells, natural killer cells and T lymphocytes and their immune checkpoints. TCM has a long history of having been used in clinical practice in China. Chinese medicine contains various chemical constituents, including alkaloids, polysaccharides, saponins and flavonoids. These components activate various immune cells, thereby improving systemic functions and maintaining overall health. In this review, recent progress in relation to bioactive compounds derived from TCM will be covered, including TCM alkaloids, polysaccharides, saponins and flavonoids. This study provides a basis for further in-depth research and development in the field of anti-tumor immunomodulation using bioactive compounds from TCM.
肿瘤微环境（TME）可以帮助肿瘤细胞逃避免疫细胞的监视和清除，从而创造有利于肿瘤细胞生长的内部环境。因此，人们越来越关注通过调节 TME 中的免疫细胞来研究抗肿瘤免疫。众所周知，传统中药（TCM）中的各种生物活性化合物通过调节 TME 中免疫细胞的活性来改变免疫平衡。反过来，这增强了身体的免疫反应，从而促进了肿瘤细胞的有效消除。本研究旨在整合 TCM 生物活性化合物对 TME 中免疫细胞的调节作用的最新发现。TCM 的生物活性化合物通过调节巨噬细胞、树突状细胞、自然杀伤细胞和 T 淋巴细胞及其免疫检查点来调节 TME。TCM 在临床实践中的应用在中国有着悠久的历史。中药含有各种化学成分，包括生物碱、多糖、皂苷和类黄酮。这些成分激活各种免疫细胞，从而改善全身功能，保持整体健康。本综述涵盖了源自 TCM 的生物活性化合物的最新进展，包括 TCM 生物碱、多糖、皂苷和类黄酮。本研究为进一步深入研究 TCM 生物活性化合物在抗肿瘤免疫调节中的应用提供了基础。
