Ayala A G, Srigley J R, Ro J Y, Abdul-Karim F W, Johnson D E
Am J Surg Pathol. 1986 Oct;10(10):665-71. doi: 10.1097/00000478-198610000-00001.
We report 10 patients with clear cell cribriform hyperplasia of the prostate. Their ages ranged from 62 to 87 years, with a mean of 72 years. The clinical diagnosis in all patients was benign nodular hyperplasia; all the patients are alive and have shown no evidence of recurrent disease. Follow-ups ranged from 1 month to 7 years (median: 12.5 months; mean: 24.6 months). Pathologically, this lesion has a cribriform arrangement of clear cells with a complex papillary growth simulating the cribriform pattern of prostatic carcinoma. In fact, in five of the 10 cases, the referring diagnosis was either carcinoma or possible carcinoma. Cytologically, however, there is no nuclear atypia, mitosis, or prominent nucleoli, and typically there is a double epithelial cell layer at the periphery of the involved acini. In summary, clear cell cribriform hyperplasia is a benign hyperplastic process with a complex papillary-cribriform structure and should not be confused with prostatic carcinoma. The key feature for the diagnosis is the preservation of nodular configuration with a bland cytology and double cell layer lining the involved acini.
我们报告了10例前列腺透明细胞筛状增生患者。他们的年龄在62岁至87岁之间，平均年龄为72岁。所有患者的临床诊断均为良性结节性增生；所有患者均存活，且无疾病复发迹象。随访时间从1个月至7年不等（中位数：12.5个月；平均：24.6个月）。病理上，该病变具有透明细胞的筛状排列，并伴有复杂的乳头状生长，类似前列腺癌的筛状模式。事实上，在10例病例中的5例中，最初的诊断为癌或可能为癌。然而，在细胞学上，没有核异型性、有丝分裂或明显的核仁，并且在受累腺泡的周边通常有双层上皮细胞。总之，透明细胞筛状增生是一种具有复杂乳头状 - 筛状结构的良性增生过程，不应与前列腺癌相混淆。诊断的关键特征是保留结节形态，细胞学表现温和，受累腺泡内衬双层细胞。
