Brawn P N, Speights V O, Contin J U, Bayardo R J, Kuhl D L
Department of Anatomic Pathology, Veterans Administration Medical Center, Temple, Texas.
J Clin Pathol. 1989 Apr;42(4):383-6. doi: 10.1136/jcp.42.4.383.
One hundred prostates from 20 to 40 year old men obtained at necropsy were completely sectioned and studied microscopically. Atypical hyperplasia was found in 10 (20%) of 20-29 year old men and in 12 (24%) of 30-40 year old men. The prostates with atypical hyperplasia had similar weights as those without, and the atypical hyperplasia was most common in the lateral lobes of the prostate and near the apex. The atypical hyperplasias were (i) usually mild in degree rather than moderate or severe; (ii) almost equally divided between circumscribed and "infiltrating" lesions; (iii) usually occurred as multiple foci within the same prostate rather than as a single focus of atypical hyperplasia; and (iv) were not associated with inflammation. The finding that atypical hyperplasia is common in men between the ages of 20 and 40 years may be helpful in increasing the understanding of the histopathology of the prostate.
对20至40岁男性尸检时获取的100个前列腺进行完整切片并做显微镜检查。在20至29岁男性中有10例（20%）发现非典型增生，在30至40岁男性中有12例（24%）发现非典型增生。有非典型增生的前列腺与无此病变的前列腺重量相似，非典型增生在前列腺侧叶及近尖部最为常见。这些非典型增生具有以下特点：（i）程度通常较轻而非中度或重度；（ii）界限清楚的病变与“浸润性”病变几乎各占一半；（iii）通常在同一前列腺内表现为多个病灶，而非单个非典型增生病灶；（iv）与炎症无关。20至40岁男性中常见非典型增生这一发现，可能有助于增进对前列腺组织病理学的理解。
