Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Ann Am Thorac Soc. 2023 Nov;20(11):1614-1623. doi: 10.1513/AnnalsATS.202305-481OC.
Intimate partner violence and child maltreatment have been separately associated with asthma in adults. No study has concurrently examined of adulthood adverse events (including, but not limited to, intimate partner violence) and child maltreatment on asthma in adults. To concurrently examine of adulthood adverse events and child maltreatment on asthma in adults. This was a cross-sectional study of adulthood adverse events and child maltreatment on current asthma in 87,891 adults 40-69 years old who participated in the UK Biobank. Adulthood adverse events were assessed using questions adapted from a national crime survey. Child maltreatment was ascertained using the Childhood Trauma Screener questionnaire. Current asthma was defined as physician-diagnosed asthma and current wheeze and was further classified as noneosinophilic or eosinophilic according to eosinophil count (<300 vs. ⩾300 cells per microliter). In a multivariable analysis, participants who reported two or more types of adulthood adverse events had 1.19-1.45 times significantly higher odds of asthma than those who did not, whereas participants who reported two or more types of child maltreatment had 1.25-1.59 significantly higher odds of asthma than those who reported no child maltreatment. After stratification by sex, similar results were obtained for child maltreatment in women and men, whereas adulthood adverse events were only significantly associated with asthma in women. Similar findings were observed in analyses that were restricted to never-smokers and former smokers with <10 pack-years of smoking and in analyses of noneosinophilic and eosinophilic asthma. In a cohort of British adults, child maltreatment was associated with current asthma in men and women, whereas adulthood adverse events were associated with current asthma in women only. This was independent of cigarette smoking or eosinophil count.
亲密伴侣暴力和儿童虐待已分别与成年人的哮喘有关。目前还没有研究同时检查成年期不良事件（包括但不限于亲密伴侣暴力）和儿童虐待对成年人哮喘的影响。本研究旨在同时探讨成年期不良事件和儿童虐待对成年人哮喘的影响。这是一项横断面研究，共纳入 87891 名 40-69 岁的英国生物银行参与者，评估成年期不良事件和儿童虐待与当前哮喘的关系。成年期不良事件采用改编自全国犯罪调查的问题进行评估。儿童虐待采用儿童创伤筛查问卷进行确定。当前哮喘定义为医生诊断的哮喘和当前喘息，并根据嗜酸性粒细胞计数（<300 与 ⩾300 个细胞/微升）进一步分为非嗜酸性粒细胞或嗜酸性粒细胞哮喘。多变量分析显示，报告两种或两种以上类型成年期不良事件的参与者患哮喘的可能性比未报告的参与者高 1.19-1.45 倍，而报告两种或两种以上类型儿童虐待的参与者患哮喘的可能性比未报告儿童虐待的参与者高 1.25-1.59 倍。按性别分层后，在女性和男性中也观察到类似的儿童虐待结果，而成年期不良事件仅与女性哮喘显著相关。在从未吸烟者和前吸烟者（吸烟 ⩽10 包年）以及非嗜酸性粒细胞和嗜酸性粒细胞哮喘的分析中也观察到了类似的结果。在英国成年人队列中，儿童虐待与男性和女性的当前哮喘有关，而成年期不良事件仅与女性的当前哮喘有关。这与吸烟或嗜酸性粒细胞计数无关。
