Zhang Zheng, Wang Yating, Li Jiazheng, Ren Hao, Wang Xinglian, Qiu Haitang, Luo Huirong, Wang Xueqian, Li Junyao, Hu Renqin, Guo Yanwei, Tan Jinglan, Jiang Chenggang, Luo Qinghua
Department of Sleep and Psychology, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China.
Department of Sleep and Psychology, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Eur J Psychotraumatol. 2025 Dec;16(1):2383127. doi: 10.1080/20008066.2024.2383127. Epub 2025 Apr 14.
Prior research indicates a potential connection between childhood maltreatment and asthma. In response, we designed a Mendelian Randomization (MR) study to further investigate this association. Utilizing the MR approach, we leveraged Genome-Wide Association Studies (GWAS) data from the UK Biobank (UKB). Our primary outcome was asthma, analyzed through GWAS datasets termed AsthmaUKB and AsthmaIEU, sourced from two distinct studies. Additionally, we conducted stratified analyses focusing on pediatric asthma and adult asthma to address different asthma phenotypes. The causal impact of childhood maltreatment (CM) on asthma was assessed using inverse-variance weighted (IVW) methods, MR-Egger, and MR-PRESSO tests, thereby enhancing the robustness and generalizability of our findings. The IVW analyses identified significant associations between CM and increased risks for AsthmaUKB ( = 1.59, 95% = 1.23-2.05, < .001), AsthmaIEU ( = 1.04, 95% = 1.02-1.06, < .001), pediatric asthma ( = 1.72, 95% = 1.26-2.35, = .001), and adult asthma ( = 1.71, 95% = 1.17-2.48, = .005). The MR-Egger and MR-PRESSO results confirmed the absence of pleiotropy, reinforcing our causal inferences. Although Cochran's test indicated some heterogeneity among asthma subtypes ( > .05), the robustness of the IVW results remains reliable. Our findings suggest a potential causal relationship between CM and various asthma phenotypes, as validated through rigorous Mendelian randomization analyses. These results emphasize the importance of considering CM in asthma prevention and intervention strategies and lay the groundwork for further investigation into how early-life adversities may predispose individuals to asthma, contributing to a deeper understanding of its etiological pathways.
先前的研究表明童年期虐待与哮喘之间存在潜在联系。作为回应，我们设计了一项孟德尔随机化（MR）研究，以进一步探究这种关联。利用MR方法，我们利用了来自英国生物银行（UKB）的全基因组关联研究（GWAS）数据。我们的主要结局是哮喘，通过来自两项不同研究的名为AsthmaUKB和AsthmaIEU的GWAS数据集进行分析。此外，我们进行了分层分析，重点关注儿童哮喘和成人哮喘，以应对不同的哮喘表型。使用逆方差加权（IVW）方法、MR-Egger和MR-PRESSO检验评估童年期虐待（CM）对哮喘的因果影响，从而增强我们研究结果的稳健性和普遍性。IVW分析确定了CM与AsthmaUKB（比值比=1.59，95%置信区间=1.23-2.05，P<0.001）、AsthmaIEU（比值比=1.04，95%置信区间=1.02-1.06，P<0.001）、儿童哮喘（比值比=1.72，95%置信区间=1.26-2.35，P=0.001）和成人哮喘（比值比=1.71，95%置信区间=1.17-2.48，P=0.005）风险增加之间存在显著关联。MR-Egger和MR-PRESSO结果证实不存在多效性，加强了我们的因果推断。尽管 Cochr an检验表明哮喘亚型之间存在一些异质性（P>0.05），但IVW结果的稳健性仍然可靠。我们的研究结果表明，通过严格的孟德尔随机化分析验证，CM与各种哮喘表型之间存在潜在的因果关系。这些结果强调了在哮喘预防和干预策略中考虑CM的重要性，并为进一步研究早期生活逆境如何使个体易患哮喘奠定了基础，有助于更深入地了解其病因途径。
