在欧洲人群中，咖啡/咖啡因摄入与阻塞性睡眠呼吸暂停风险之间的遗传关联：一项两样本孟德尔随机化研究。
Genetic association between coffee/caffeine consumption and the risk of obstructive sleep apnea in the European population: a two-sample Mendelian randomization study.
机构信息
Department of Psychiatry, Wuhan Mental Health Center, Wuhan, 430012, Hubei, China.
Department of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan, 430012, Hubei, China.
出版信息
Eur J Nutr. 2023 Dec;62(8):3423-3431. doi: 10.1007/s00394-023-03239-0. Epub 2023 Sep 5.
BACKGROUND
The association between coffee/caffeine consumption and obstructive sleep apnea (OSA) risk remains unclear.
PURPOSE
To determine the relationship between coffee/caffeine consumption and the risk of OSA, using the Mendelian randomization (MR) method in the European population.
METHODS
Two sets of coffee consumption-associated genetic variants were, respectively, extracted from the recent genome-wide meta-analysis (GWMA) and genome-wide association study (GWAS) of coffee consumption. Taking other caffeine sources into account, genetic variants associated with caffeine consumption from tea and plasma caffeine (reflecting total caffeine intake) were also obtained. The inverse variance weighted (IVW) technique was utilized as the primary analysis, supplemented by the MR-Egger, weighted-median, and MR-Pleiotropy RESidual Sum and Outlier (PRESSO) techniques. Leave-one-out (LOO) analysis was performed to assess whether the overall casual estimates were driven by a single SNP. Additional sensitivity analyses were performed using similar methods, while the genetic variants associated with confounders, e.g., body mass index and hypertension, were excluded.
RESULTS
The IVW method demonstrated that coffee consumption GWMA (OR: 1.065, 95% CI 0.927-1.224, p = 0.376), coffee consumption GWAS (OR: 1.665, 95% CI 0.932-2.977, p = 0.086), caffeine from tea (OR: 1.198, 95% CI 0.936-1.534, p = 0.151), and blood caffeine levels (OR: 1.054, 95% CI 0.902-1.231, p = 0.508) were unlikely to be associated with the risk of OSA. The other three methods presented similar results, where no significant associations were found. No single genetic variant was driving the overall estimates by the LOO analysis. These findings were also supported by the sensitivity analyses with no confounding genetic variants.
CONCLUSION
Our study found no association between coffee/caffeine consumption and the risk of OSA.
背景
咖啡/咖啡因摄入与阻塞性睡眠呼吸暂停（OSA）风险之间的关联仍不清楚。
目的
使用欧洲人群中的孟德尔随机化（MR）方法，确定咖啡/咖啡因摄入与 OSA 风险之间的关系。
方法
分别从最近的咖啡消费全基因组荟萃分析（GWMA）和咖啡消费全基因组关联研究（GWAS）中提取两组咖啡消费相关的遗传变异。考虑到其他咖啡因来源，还获得了与茶和血浆咖啡因（反映总咖啡因摄入量）相关的与咖啡因消费相关的遗传变异。采用逆方差加权（IVW）技术作为主要分析方法，并补充了 MR-Egger、加权中位数和 MR-Pleiotropy RESidual Sum and Outlier（PRESSO）技术。进行了留一法（LOO）分析，以评估整体因果估计是否受单个 SNP 驱动。使用类似的方法进行了额外的敏感性分析，同时排除了与混杂因素（如体重指数和高血压）相关的遗传变异。
结果
IVW 方法表明，咖啡消费 GWMA（OR：1.065，95%CI 0.927-1.224，p=0.376）、咖啡消费 GWAS（OR：1.665，95%CI 0.932-2.977，p=0.086）、茶中的咖啡因（OR：1.198，95%CI 0.936-1.534，p=0.151）和血液咖啡因水平（OR：1.054，95%CI 0.902-1.231，p=0.508）与 OSA 风险无关联。其他三种方法也得出了相似的结果，未发现显著关联。LOO 分析表明，没有单个遗传变异驱动整体估计。这些发现也得到了没有混杂遗传变异的敏感性分析的支持。
结论
本研究未发现咖啡/咖啡因摄入与 OSA 风险之间存在关联。
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