Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province, China.
Medicine (Baltimore). 2024 Nov 29;103(48):e40541. doi: 10.1097/MD.0000000000040541.
Bronchitis is a common respiratory disease characterized by acute inflammation, edema, and necrosis of the small airways, leading to a significant pathological burden. Immune cells play a crucial role in combating bronchitis. This study aims to explore the causal relationship between immune cells and bronchitis using the Mendelian randomization approach. In this study, we screened 18,183 single nucleotide polymorphisms highly associated with immune cells and employed 5 Mendelian randomization methods to assess the potential causal link between different types of immune cells and bronchitis. Additionally, the study utilized inverse variance weighting and MR-Egger regression analysis to evaluate the heterogeneity and robustness of the causal estimates. The study found a significant causal association between 28 types of immune cells and the risk of bronchitis. These cell types mainly included T cells, monocytes, and B cells. For instance, CD25 on B cells and CD25 on IgD+ were associated with an increased risk of bronchitis, whereas IgD+ CD24- B cells and CD33- HLA DR- AC showed a protective effect against bronchitis. Moreover, the study validated the robustness of these findings through leave-one-out analysis and the MR-Egger method, and quantitatively illustrated the impact of immune cells on the risk of bronchitis through forest plots. This study reveals the dual role of immune cells in bronchitis. The identified types of immune cells may increase the risk of bronchitis by promoting inflammatory responses and cell-mediated immune reactions, while other cell types may offer protection by promoting immune balance and effective defense.
支气管炎是一种常见的呼吸道疾病，其特征为小气道的急性炎症、水肿和坏死，导致显著的病理负担。免疫细胞在对抗支气管炎方面起着关键作用。本研究旨在采用孟德尔随机化方法探索免疫细胞与支气管炎之间的因果关系。本研究筛选了与免疫细胞高度相关的 18183 个单核苷酸多态性，并采用 5 种孟德尔随机化方法评估不同类型免疫细胞与支气管炎之间的潜在因果关联。此外，该研究还利用逆方差加权和 MR-Egger 回归分析评估了因果估计的异质性和稳健性。研究发现 28 种免疫细胞与支气管炎风险之间存在显著的因果关联。这些细胞类型主要包括 T 细胞、单核细胞和 B 细胞。例如，B 细胞上的 CD25 和 IgD+上的 CD25 与支气管炎风险增加相关，而 IgD+CD24-B 细胞和 CD33-HLA-DR-AC 则对支气管炎具有保护作用。此外，研究通过逐一剔除分析和 MR-Egger 方法验证了这些发现的稳健性，并通过森林图定量说明了免疫细胞对支气管炎风险的影响。本研究揭示了免疫细胞在支气管炎中的双重作用。所确定的免疫细胞类型可能通过促进炎症反应和细胞介导的免疫反应而增加患支气管炎的风险，而其他细胞类型则可能通过促进免疫平衡和有效防御提供保护。
