Takashima S, Ando Y, Takeshita K
Brain Dev. 1986;8(3):274-7. doi: 10.1016/s0387-7604(86)80081-x.
Hypoxic-ischemic cerebral damage was demonstrated in the cerebral cortex of 2-week-old rabbits at 3 to 5 days after bilateral carotid artery ligation and reperfusion during hypoxemia. Carotid ligation and reperfusion had little effect on cortical blood flow during normoxemia, but the former suppressed a blood flow increase to hypoxemia and the latter suppressed a blood flow decrease to hyperoxemia. These results suggest a relative ischemia or vascular dysfunction which may play a part in the pathogenesis of the hypoxic-ischemic cortical necrosis.
在低氧血症期间双侧颈动脉结扎和再灌注后3至5天，在2周龄家兔的大脑皮层中证实了缺氧缺血性脑损伤。在正常氧合血症期间，颈动脉结扎和再灌注对皮层血流影响不大，但前者抑制了对低氧血症的血流增加，而后者抑制了对高氧血症的血流减少。这些结果提示了一种相对缺血或血管功能障碍，其可能在缺氧缺血性皮层坏死的发病机制中起作用。
