Ninane J, Wese F X
Am J Pediatr Hematol Oncol. 1986 Fall;8(3):248-52. doi: 10.1097/00043426-198623000-00014.
The treatment of neuroblastoma must take into account the prognosis as determined at the time of diagnosis. The stage is an important prognostic factor. In Evans's Stage I neuroblastoma, surgery is curative in itself and adjuvant treatment is not needed. In Evans' Stage II, it is our opinion that the presence of involved lymph nodes worsens the prognosis. Therefore, we suggest that patients with Stage II should be divided into Stage IIA (without lymph node involvement) and Stage IIB (with lymph node involvement). The treatment of Stage IIA patients may be the same as for Stage I patients, i.e., surgery alone. However, Stage IIB patients should be treated with intensive combined chemotherapy of short duration following surgery.
神经母细胞瘤的治疗必须考虑诊断时确定的预后情况。分期是一个重要的预后因素。在埃文斯I期神经母细胞瘤中，手术本身即可治愈，无需辅助治疗。在埃文斯II期，我们认为存在受累淋巴结会使预后恶化。因此，我们建议将II期患者分为IIA期（无淋巴结受累）和IIB期（有淋巴结受累）。IIA期患者的治疗可能与I期患者相同，即仅进行手术。然而，IIB期患者术后应接受短期强化联合化疗。
