Evans A E, D'Angio G J, Koop C E
J Pediatr Surg. 1984 Feb;19(1):77-80. doi: 10.1016/s0022-3468(84)80021-4.
The records of 49 patients with local and regional neuroblastoma treated at The Children's Hospital of Philadelphia between 1972-1981 were reviewed to determine the contribution of radiation therapy and chemotherapy to their management. All 11 state I patients were treated with surgery alone and 10 (91%) survived for periods ranging from 3 to 10 years. Half of the 24 stage II patients received radiation therapy with or without chemotherapy and 8/12 (67%) survive. Ten of the 12 remaining stage II patients survive (83%) following surgery alone. All stage II patients had residual disease and 13 had involvement in lymph nodes. 7 in the combined treatment group and 6 in the surgery alone group. All 14 stage III patients received postoperative chemotherapy and radiation therapy (RT) and 7 or 50% remain disease free. We conclude that surgery alone is sufficient for patients with stage I NBL, that RT and chemotherapy do not appear to alter the outcome in stage II patients, and better methods of therapy are needed for patients with stage III disease.
回顾了1972年至1981年间在费城儿童医院接受治疗的49例局部和区域神经母细胞瘤患者的记录，以确定放射治疗和化疗在其治疗中的作用。所有11例I期患者仅接受手术治疗，10例（91%）存活3至10年。24例II期患者中有一半接受了放疗，无论是否联合化疗，8/12例（67%）存活。其余12例II期患者中，10例（83%）仅接受手术后存活。所有II期患者均有残留病灶，13例有淋巴结受累。联合治疗组7例，单纯手术组6例。所有14例III期患者均接受术后化疗和放疗（RT），7例（50%）仍无疾病。我们得出结论，对于I期神经母细胞瘤患者，单纯手术就足够了；放疗和化疗似乎不会改变II期患者的预后；对于III期疾病患者，需要更好的治疗方法。
