• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

地榆日本变种乙醇提取物对 NC/Nga 小鼠和人角质形成细胞特应性皮炎样反应的抑制作用。

Inhibitory effect of Sanguisorba hakusanensis Makino ethanol extract on atopic dermatitis-like responses in NC/Nga mice and human keratinocytes.

机构信息

KM Convergence Research Division, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon, 34054, Republic of Korea.

College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.

出版信息

Sci Rep. 2023 Sep 5;13(1):14594. doi: 10.1038/s41598-023-41676-3.

DOI:10.1038/s41598-023-41676-3
PMID:37670127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10480230/
Abstract

Atopic dermatitis (AD) is an allergic, inflammatory skin disease caused by immune dysregulation. In this study, we investigated anti-atopic and anti-inflammatory activities of Sanguisorba hakusanensis ethanol extract (SHE) both in vivo using NC/Nga mice and in vitro using human HaCaT keratinocytes. Oral administration of SHE suppressed several atopic symptoms associated with house dust mites (induced with Dermatophagoides farinae extract) in NC/Nga mice and decreased serum levels of inflammatory mediators such as immunoglobulin E, histamine, and inflammatory chemokines. Additionally, SHE treatment reduced the infiltration of immune cells such as mast cells and macrophages in AD skin lesions. In vitro, interferon-γ- and tumor necrosis factor-α-stimulated HaCaT cells exhibited increased expression of T helper 1 and 2 chemokines; their expression was inhibited by SHE treatment. The anti-inflammatory effects of SHE treatment involved blocking of the mitogen-activated protein kinase and signal transducer and activator of transcription 1 signaling pathways. In conclusion, SHE exerts potent anti-atopic and anti-inflammatory effects and should be considered for the clinical treatment of AD.

摘要

特应性皮炎（AD）是一种由免疫失调引起的过敏性炎症性皮肤病。在这项研究中，我们使用 NC/Nga 小鼠进行体内研究，使用人 HaCaT 角质形成细胞进行体外研究，研究了黄耆乙醇提取物（SHE）的抗特应性和抗炎活性。SHE 口服给药可抑制 NC/Nga 小鼠与尘螨（用屋尘螨提取物诱导）相关的几种特应性症状，并降低血清中免疫球蛋白 E、组胺和炎症趋化因子等炎症介质的水平。此外，SHE 治疗可减少 AD 皮肤病变中免疫细胞如肥大细胞和巨噬细胞的浸润。体外研究显示，干扰素-γ和肿瘤坏死因子-α刺激的 HaCaT 细胞中 T 辅助 1 和 2 趋化因子的表达增加；SHE 治疗可抑制其表达。SHE 治疗的抗炎作用涉及阻断丝裂原活化蛋白激酶和信号转导及转录激活因子 1 信号通路。总之，SHE 具有强大的抗特应性和抗炎作用，应考虑用于 AD 的临床治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/27620cfa154f/41598_2023_41676_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/ad920e252d03/41598_2023_41676_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/1e4c92b10b00/41598_2023_41676_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/84a12c7b294e/41598_2023_41676_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/65290fe642fc/41598_2023_41676_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/67c1bc6fe9fc/41598_2023_41676_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/27620cfa154f/41598_2023_41676_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/ad920e252d03/41598_2023_41676_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/1e4c92b10b00/41598_2023_41676_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/84a12c7b294e/41598_2023_41676_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/65290fe642fc/41598_2023_41676_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/67c1bc6fe9fc/41598_2023_41676_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e0b/10480230/27620cfa154f/41598_2023_41676_Fig6_HTML.jpg

相似文献

1
Inhibitory effect of Sanguisorba hakusanensis Makino ethanol extract on atopic dermatitis-like responses in NC/Nga mice and human keratinocytes.地榆日本变种乙醇提取物对 NC/Nga 小鼠和人角质形成细胞特应性皮炎样反应的抑制作用。
Sci Rep. 2023 Sep 5;13(1):14594. doi: 10.1038/s41598-023-41676-3.
2
Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production.高良姜水提取物通过调节炎症趋化因子的产生抑制 NC/Nga 小鼠的特应性皮炎样反应。
Biomed Pharmacother. 2021 Dec;144:112322. doi: 10.1016/j.biopha.2021.112322. Epub 2021 Oct 15.
3
Suppresses the Atopic Dermatitis-Like Responses in NC/Nga Mice and Inflamed HaCaT Keratinocytes via the Downregulation of STAT1.通过下调 STAT1，抑制 NC/Nga 小鼠的特应性皮炎样反应和炎症角质形成细胞。
Nutrients. 2020 Oct 23;12(11):3238. doi: 10.3390/nu12113238.
4
Inhibitory effect of ethanol extract of Ampelopsis brevipedunculata rhizomes on atopic dermatitis-like skin inflammation.白首乌块根乙醇提取物对特应性皮炎样皮肤炎症的抑制作用。
J Ethnopharmacol. 2019 Jun 28;238:111850. doi: 10.1016/j.jep.2019.111850. Epub 2019 Apr 4.
5
Terminalia chebula Retz. extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1/3 and NF-ĸB signaling in vitro.诃子提取物通过调节体内抗炎因子和体外抑制 STAT1/3 和 NF-κB 信号通路改善特应性皮炎症状。
Phytomedicine. 2022 Sep;104:154318. doi: 10.1016/j.phymed.2022.154318. Epub 2022 Jul 4.
6
Evodiae Fructus extract suppresses inflammatory response in HaCaT cells and improves house dust mite-induced atopic dermatitis in NC/Nga mice.吴茱萸果提取物可抑制 HaCaT 细胞的炎症反应，并改善 NC/Nga 小鼠尘螨诱导的特应性皮炎。
Sci Rep. 2024 Jan 4;14(1):472. doi: 10.1038/s41598-023-50257-3.
7
Luffa cylindrica suppresses development of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in Nc/Nga mice.丝瓜抑制Nc/Nga小鼠中由粉尘螨诱导的特应性皮炎样皮肤损伤的发展。
Pharm Biol. 2015 Apr;53(4):555-62. doi: 10.3109/13880209.2014.932392. Epub 2014 Oct 20.
8
Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells.枳椇提取物和香草酸甲酯对特应性皮炎样皮肤损伤及肿瘤坏死因子-α/干扰素-γ诱导的人永生化角质形成细胞趋化因子产生的影响
J Pharm Pharmacol. 2016 Nov;68(11):1465-1479. doi: 10.1111/jphp.12640. Epub 2016 Oct 2.
9
Gardenia jasminoides extract without crocin improved atopic dermatitis-like skin lesions via suppression of Th2-related cytokines in Dfe-induced NC/Nga mice.栀子提取物去藏红花素通过抑制 Dfe 诱导的 NC/Nga 小鼠中 Th2 相关细胞因子改善特应性皮炎样皮肤损伤。
J Ethnopharmacol. 2019 Sep 15;241:112015. doi: 10.1016/j.jep.2019.112015. Epub 2019 Jun 4.
10
Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.雪莲通过抑制 HaCaT 细胞炎症趋化因子的产生和 Nc/Nga 小鼠屋尘螨诱导的特应性皮炎发挥抗炎作用。
Food Chem Toxicol. 2014 Jan;63:212-20. doi: 10.1016/j.fct.2013.10.050. Epub 2013 Nov 8.

引用本文的文献

1
Saccharomyces boulardii (CNCM I-745) ameliorates Ovalbumin-induced atopic dermatitis by modulating the NF-κB signaling in skin and colon.布拉氏酵母菌（CNCM I-745）通过调节皮肤和结肠中的NF-κB信号通路改善卵清蛋白诱导的特应性皮炎。
Arch Dermatol Res. 2025 Feb 26;317(1):500. doi: 10.1007/s00403-025-04057-6.
2
Rosmarinic Acid Ameliorates Extract-Induced Atopic Dermatitis-like Skin Inflammation by Activating the Nrf2/HO-1 Signaling Pathway.迷迭香酸通过激活Nrf2/HO-1信号通路改善提取物诱导的特应性皮炎样皮肤炎症。
Int J Mol Sci. 2024 Nov 27;25(23):12737. doi: 10.3390/ijms252312737.
3
Anti-Inflammatory Activities of Yataprasen Thai Traditional Formulary and Its Active Compounds, Beta-Amyrin and Stigmasterol, in RAW264.7 and THP-1 Cells.

本文引用的文献

1
Atopic Dermatitis: Striving for Reliable Biomarkers.特应性皮炎：寻求可靠的生物标志物。
J Clin Med. 2022 Aug 9;11(16):4639. doi: 10.3390/jcm11164639.
2
Peripheral itch sensitization in atopic dermatitis.特应性皮炎的外周瘙痒敏化。
Allergol Int. 2022 Jul;71(3):265-277. doi: 10.1016/j.alit.2022.04.003. Epub 2022 May 25.
3
Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes.槲皮素可改善特应性皮炎模型中人类角质形成细胞的炎症、氧化应激和受损的伤口愈合。
泰国传统配方药亚他普瑞森及其活性成分β-香树脂醇和豆甾醇在RAW264.7和THP-1细胞中的抗炎活性
Pharmaceuticals (Basel). 2024 Aug 1;17(8):1018. doi: 10.3390/ph17081018.
4
extract prevents atopic dermatitis in DNCB-induced mice.提取物可预防二硝基氯苯诱导的小鼠特应性皮炎。
Food Sci Biotechnol. 2024 Feb 29;33(11):2643-2652. doi: 10.1007/s10068-024-01523-1. eCollection 2024 Aug.
Pediatr Allergy Immunol Pulmonol. 2020 Jun;33(2):69-79. doi: 10.1089/ped.2019.1137. Epub 2020 May 21.
4
Water Extract of Prevents Inflammatory Skin Diseases In Vitro Models.[提取物名称]的水提取物在体外模型中预防炎症性皮肤病。 （注：原文“Water Extract of ”后缺少具体提取物名称）
Plants (Basel). 2021 Jun 17;10(6):1230. doi: 10.3390/plants10061230.
5
Novel Oxovanadium Complex VO(hntdtsc)(NPIP): Anticancer Activity and Mechanism of Action on HeLa Cells.新型氧钒配合物VO(hntdtsc)(NPIP)：对HeLa细胞的抗癌活性及作用机制
Front Pharmacol. 2021 Feb 8;11:608218. doi: 10.3389/fphar.2020.608218. eCollection 2020.
6
Anti-Inflammatory Effects of Ellagic Acid on Keratinocytes via MAPK and STAT Pathways.鞣花酸通过 MAPK 和 STAT 通路对角质形成细胞的抗炎作用。
Int J Mol Sci. 2021 Jan 28;22(3):1277. doi: 10.3390/ijms22031277.
7
Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council.特应性皮炎的生物标志物——国际特应性皮炎理事会综述。
J Allergy Clin Immunol. 2021 Apr;147(4):1174-1190.e1. doi: 10.1016/j.jaci.2021.01.013. Epub 2021 Jan 28.
8
Suppresses the Atopic Dermatitis-Like Responses in NC/Nga Mice and Inflamed HaCaT Keratinocytes via the Downregulation of STAT1.通过下调 STAT1，抑制 NC/Nga 小鼠的特应性皮炎样反应和炎症角质形成细胞。
Nutrients. 2020 Oct 23;12(11):3238. doi: 10.3390/nu12113238.
9
Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.地榆（Sanguisorba officinalis L.）来源于草药，通过诱导巨噬细胞自噬来预防肠道炎症。
Sci Rep. 2020 Jun 19;10(1):9972. doi: 10.1038/s41598-020-65306-4.
10
Quercetin with the potential effect on allergic diseases.槲皮素对过敏性疾病具有潜在作用。
Allergy Asthma Clin Immunol. 2020 May 14;16:36. doi: 10.1186/s13223-020-00434-0. eCollection 2020.