Shibasaki Shota, Mitri Sara
Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
iScience. 2023 Jul 31;26(9):107499. doi: 10.1016/j.isci.2023.107499. eCollection 2023 Sep 15.
Given the importance of gut microbial communities for human health, we may want to ensure their stability in terms of species composition and function. Here, we built a mathematical model of a simplified gut composed of two connected patches where species and metabolites can flow from an upstream patch, allowing upstream species to affect downstream species' growth. First, we found that communities in our model are more stable if they assemble through species invasion over time compared to combining a set of species from the start. Second, downstream communities are more stable when species invade the downstream patch less frequently than the upstream patch. Finally, upstream species that have positive effects on downstream species can further increase downstream community stability. Despite it being quite abstract, our model may inform future research on designing more stable microbial communities or increasing the stability of existing ones.
鉴于肠道微生物群落对人类健康的重要性，我们可能希望确保它们在物种组成和功能方面的稳定性。在此，我们构建了一个简化肠道的数学模型，该肠道由两个相连的区域组成，物种和代谢物可以从上游区域流动，使上游物种能够影响下游物种的生长。首先，我们发现，与一开始就组合一组物种相比，我们模型中的群落如果随着时间通过物种入侵而组装，则会更稳定。其次，当物种向下游区域入侵的频率低于上游区域时，下游群落会更稳定。最后，对下游物种有积极影响的上游物种可以进一步提高下游群落的稳定性。尽管我们的模型相当抽象，但它可能为未来关于设计更稳定的微生物群落或提高现有微生物群落稳定性的研究提供参考。
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