Heidari-Soureshjani Reza, Nasrabadi Alireza Nikbakht, Zakerimoghadam Masoumeh, Mohammadi Tayeb, Rasti Arezoo
School of Nursing and Midwifery Tehran University of Medical Sciences Tehran Iran.
Department of Biostatistics, School of Public Health Hamadan University of Medical Sciences Hamadan Iran.
Health Sci Rep. 2023 Sep 4;6(9):e1536. doi: 10.1002/hsr2.1536. eCollection 2023 Sep.
Educational self-management interventions (SMI) have an important role in improving symptom management, preventing relapse of multiple sclerosis (MS) and promoting quality of life (QoL) of these patients; since there is little knowledge about overall effectiveness of MS self-management programs and which types of SMI improves the outcomes, this research aims to assess the efficacy of structured SMI in improving health outcomes in people with MS (PwMS) by synthesizing and compare outcomes from related randomized controlled trials.
In the present systematic review protocol, the keywords related to self-management and MS will be searched in electronic databases including (PubMed, Web of Science, Scopus, EMBASE, Cochrane Central Register of Controlled Trials [CENTRAL]), gray literature resources and key journals from 2000 to July 2023. Research-related articles will be collected and after removing duplicate articles, will be included in the study. In the screening step, titles and abstracts of articles will be reviewed and after deleting irrelevant articles, the full text of related articles will be evaluated independently by two researchers and data will be extracted from final articles and the findings will be categorized in an extraction table. Risk of bias will be assessed by using the Cochrane collaboration's tool. If possible, the data will be analyzed using random effect models and the statistical analysis will be performed using STATA software (version 14.2) developed by StataCorp.
Comparative effectiveness of SMI is currently unknown. We will analyze outcome measures used to assess effectiveness of self-management education in improving QoL, depression, self-efficacy, pain, and fatigue. These findings will help identify the most promising components of SMIs, guiding targeted interventions for specific subpopulations, and facilitating the design of better interventions.
教育自我管理干预措施（SMI）在改善症状管理、预防多发性硬化症（MS）复发以及提高这些患者的生活质量（QoL）方面具有重要作用；由于对MS自我管理项目的整体有效性以及哪种类型的SMI能改善结果了解甚少，本研究旨在通过综合和比较相关随机对照试验的结果，评估结构化SMI对改善MS患者（PwMS）健康结局的疗效。
在本系统评价方案中，将在包括（PubMed、科学网、Scopus、EMBASE、Cochrane对照试验中心注册库[CENTRAL]）在内的电子数据库、灰色文献资源以及2000年至2023年7月的重点期刊中搜索与自我管理和MS相关的关键词。收集与研究相关的文章，去除重复文章后纳入研究。在筛选步骤中，将对文章的标题和摘要进行审查，并删除无关文章，两名研究人员将独立评估相关文章的全文，从最终文章中提取数据，并将结果分类到提取表中。将使用Cochrane协作工具评估偏倚风险。如果可能，将使用随机效应模型进行数据分析，并使用StataCorp开发的STATA软件（版本14.2）进行统计分析。
目前尚不清楚SMI的比较有效性。我们将分析用于评估自我管理教育在改善QoL、抑郁、自我效能、疼痛和疲劳方面有效性的结局指标。这些发现将有助于确定SMI中最有前景的组成部分，指导针对特定亚人群的靶向干预，并促进更好干预措施的设计。
