Guglielmo Valentina, Horowicz Mathilde, Dubi Guillaume, Leszek Alexandre
Service de médecine interne, Groupement hospitalier de l'Ouest lémanique, 1260 Nyon.
Rev Med Suisse. 2023 Sep 6;19(840):1619-1623. doi: 10.53738/REVMED.2023.19.840.1619.
Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by dyspnea (platypnea) and arterial desaturation (orthodeoxia) upon changing from a lying to a standing or sitting position. The underlying physiopathological mechanisms involved are complex. Hypoxemia is attributed to the mixing of deoxygenated venous blood with arterial blood through a shunt, which can be intracardiac, or extracardiac. Patent foramen ovale is the main cause of intracardiac shunting. The transthoracic bubble contrast echocardiogram with intravenous agited saline is the most important test in the diagnosis process. Management is specific to the underlying etiology.
平卧呼吸-直立性低氧血症综合征（POS）是一种罕见的临床综合征，其特征为从卧位改为站立位或坐位时出现呼吸困难（平卧呼吸）和动脉血氧饱和度降低（直立性低氧血症）。所涉及的潜在生理病理机制很复杂。低氧血症归因于脱氧静脉血通过分流与动脉血混合，分流可为心内分流或心外分流。卵圆孔未闭是心内分流的主要原因。经胸气泡对比超声心动图联合静脉注射搅动生理盐水是诊断过程中最重要的检查。治疗方法因潜在病因而异。
