Lolin Y, O'Gorman P
Ann Clin Biochem. 1986 Sep;23 ( Pt 5):521-8. doi: 10.1177/000456328602300506.
The activity of delta-aminolaevulinic acid dehydratase (ALA-D; porphobilinogen synthase) was measured in whole blood from a group of workers with acute exposure to lead and with low blood lead levels, a group of workers with chronic lead exposure and high blood lead levels, and a group of people without undue environmental lead exposure. The activity of ALA-D was reduced significantly at low blood lead levels only if undue exposure to lead had occurred, and was thus a reflection of low level lead poisoning. In chronic lead exposure the enzyme was not invariably reactivated fully with dithiothreitol, indicating more severe enzyme poisoning. The one lead worker with symptomatic lead poisoning had the most marked enzyme suppression. Measurement of both ALA-D activity and blood lead levels was more useful than the measurement of blood lead levels alone in the diagnosis and assessment of the severity of lead poisoning.
对一组急性铅暴露且血铅水平较低的工人、一组慢性铅暴露且血铅水平较高的工人以及一组无过度环境铅暴露的人群的全血进行了δ-氨基乙酰丙酸脱水酶（ALA-D；胆色素原合酶）活性测定。仅在发生过度铅暴露时，血铅水平较低时ALA-D活性才会显著降低，因此它反映了低水平铅中毒。在慢性铅暴露中，该酶用二硫苏糖醇并非总能完全重新激活，这表明酶中毒更严重。那名有症状铅中毒的铅作业工人酶抑制最为明显。在铅中毒的诊断和严重程度评估中，同时测量ALA-D活性和血铅水平比单独测量血铅水平更有用。
