Ambali Suleiman F, Orieji Chinedu, Abubakar Woziri O, Shittu Muftau, Kawu Mohammed U
Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria 800007, Nigeria.
J Thyroid Res. 2011;2011:214924. doi: 10.4061/2011/214924. Epub 2011 May 23.
The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 animals each. Groups I and II were administered soya oil (2 mL/kg) and vitamin C (100 mg/kg), respectively. Group III was coadministered CPF (4.25 mg/kg ~1/20th LD(50)) and Pb (250 mg/kg ~1/20th LD(50)), respectively. Group IV was pretreated with vitamin C (100 mg/kg) and then coadministered with CPF (4.25 mg/kg) and Pb (250 mg/kg), 30 min later. The regimens were administered by gavage for a period of 9 weeks. The marginal decrease in serum triiodothyronine and thyroxine and the significant increase in the concentrations of thyroid stimulating hormone and malonaldehyde in the group coadministered with CPF and Pb were ameliorated by vitamin C partly due to its antioxidant properties.
本研究评估了维生素C对低剂量亚慢性联合施用毒死蜱（CPF）和铅（Pb）所致甲状腺激素变化的改善作用。将40只Wistar大鼠分为4组，每组10只动物。第一组和第二组分别给予大豆油（2 mL/kg）和维生素C（100 mg/kg）。第三组分别联合施用CPF（4.25 mg/kg，约为半数致死量的1/20）和Pb（250 mg/kg，约为半数致死量的1/20）。第四组先用维生素C（100 mg/kg）预处理，30分钟后再联合施用CPF（4.25 mg/kg）和Pb（250 mg/kg）。通过灌胃给药9周。联合施用CPF和Pb的组中血清三碘甲状腺原氨酸和甲状腺素的轻微下降以及促甲状腺激素和丙二醛浓度的显著升高，部分由于维生素C的抗氧化特性而得到改善。
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