一名铅作业工人的铅卟啉病（δ-氨基-γ-酮戊酸脱水酶缺乏症）：一个可能导致诊断混淆的病例
Plumboporphyria (ALAD deficiency) in a lead worker: a scenario for potential diagnostic confusion.
作者信息
Dyer J, Garrick D P, Inglis A, Pye I F
机构信息
Department of Neurology, Leicester Royal Infirmary.
出版信息
Br J Ind Med. 1993 Dec;50(12):1119-21. doi: 10.1136/oem.50.12.1119.
Abstract
A lead worker developed bilateral wrist drop. At first this seemed to be a lead neuropathy but all his screening tests for blood and urine toxicity had been within the accepted safety limit during employment. Detailed investigation showed that he had plumboporphyria (ALAD deficiency) which had been symptom free until he was exposed to lead. Details of his porphyrin metabolism are presented.
摘要
一名铅作业工人出现双侧垂腕。起初，这似乎是铅中毒性神经病，但他所有血液和尿液毒性的筛查测试在工作期间均处于公认的安全限度内。详细调查显示，他患有铅卟啉病（δ-氨基-γ-酮戊酸脱水酶缺乏症），在接触铅之前一直没有症状。本文介绍了他的卟啉代谢详情。
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Plumboporphyria (ALAD deficiency) in a lead worker: a scenario for potential diagnostic confusion.一名铅作业工人的铅卟啉病（δ-氨基-γ-酮戊酸脱水酶缺乏症）：一个可能导致诊断混淆的病例
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本文引用的文献
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Lead poisoning in inherited delta-aminolevulinic acid dehydratase deficiency.遗传性δ-氨基-γ-酮戊酸脱水酶缺乏所致铅中毒
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Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level.铅中毒研究。II. 全血中活化与失活的δ-氨基-γ-酮戊酸脱水酶比值与血铅水平的相关性。
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delta-Aminolaevulinic acid dehydratase as an index of the presence and severity of lead poisoning in acute and chronic lead exposure.δ-氨基乙酰丙酸脱水酶作为急性和慢性铅暴露中铅中毒存在及严重程度的一项指标。
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In inherited porphyrias, lead intoxication is a toxogenetic disorder.在遗传性卟啉病中，铅中毒是一种中毒性遗传病。
Int J Biochem. 1987;19(8):717-20. doi: 10.1016/0020-711x(87)90086-3.
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Determination of lead in blood using electrothermal atomisation atomic absorption spectrometry with a L'vov platform and matrix modifier.使用带L'vov平台和基体改进剂的电热原子化原子吸收光谱法测定血液中的铅
Analyst. 1987 Dec;112(12):1701-4. doi: 10.1039/an9871201701.
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delta-aminolevulinic acid dehydratase in low level lead exposure.低水平铅暴露中的δ-氨基乙酰丙酸脱水酶
Arch Environ Health. 1976 Jul-Aug;31(4):211-5. doi: 10.1080/00039896.1976.10667221.
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Modified erythrocyte uroporphyrinogen I synthase assay, and its clinical interpretation.改良红细胞尿卟啉原I合酶测定及其临床解读。
Clin Chem. 1978 Oct;24(10):1751-4.
8
New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation.一种新型肝性卟啉病，伴有胆色素原合酶缺陷及间歇性急性临床表现。
Klin Wochenschr. 1979 Oct 15;57(20):1123-7. doi: 10.1007/BF01481493.
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