一名铅作业工人的铅卟啉病（δ-氨基-γ-酮戊酸脱水酶缺乏症）：一个可能导致诊断混淆的病例
Plumboporphyria (ALAD deficiency) in a lead worker: a scenario for potential diagnostic confusion.
作者信息
Dyer J, Garrick D P, Inglis A, Pye I F
机构信息
Department of Neurology, Leicester Royal Infirmary.
出版信息
Br J Ind Med. 1993 Dec;50(12):1119-21. doi: 10.1136/oem.50.12.1119.
Abstract
A lead worker developed bilateral wrist drop. At first this seemed to be a lead neuropathy but all his screening tests for blood and urine toxicity had been within the accepted safety limit during employment. Detailed investigation showed that he had plumboporphyria (ALAD deficiency) which had been symptom free until he was exposed to lead. Details of his porphyrin metabolism are presented.
摘要
一名铅作业工人出现双侧垂腕。起初，这似乎是铅中毒性神经病，但他所有血液和尿液毒性的筛查测试在工作期间均处于公认的安全限度内。详细调查显示，他患有铅卟啉病（δ-氨基-γ-酮戊酸脱水酶缺乏症），在接触铅之前一直没有症状。本文介绍了他的卟啉代谢详情。
相似文献
1
Plumboporphyria (ALAD deficiency) in a lead worker: a scenario for potential diagnostic confusion.一名铅作业工人的铅卟啉病（δ-氨基-γ-酮戊酸脱水酶缺乏症）：一个可能导致诊断混淆的病例
Br J Ind Med. 1993 Dec;50(12):1119-21. doi: 10.1136/oem.50.12.1119.
2
[ALAD deficiency porphyria (ADP)].[δ-氨基-γ-酮戊酸脱水酶缺乏性卟啉症（ADP）]
Ryoikibetsu Shokogun Shirizu. 1998(19 Pt 2):139-40.
3
Lead poisoning and blistering of the skin.铅中毒与皮肤水疱
Scott Med J. 1974 Jan;19(1):3-6. doi: 10.1177/003693307401900103.
4
[Liver porphyria in a subject occupationally exposed to inorganic lead (author's transl)].
Med Lav. 1980 Jul-Aug;71(4):353-6.
5
Acute lead poisoning in inherited porphobilinogen synthase (delta-aminolevulinic acid dehydrase) deficiency.遗传性胆色素原合酶（δ-氨基乙酰丙酸脱水酶）缺乏症中的急性铅中毒
Blut. 1982 Aug;45(2):131-9. doi: 10.1007/BF00319941.
6
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal.射击场空气中铅导致的铅中毒。对一种有毒重金属的不寻常暴露。
Am J Med. 1977 Aug;63(2):306-12. doi: 10.1016/0002-9343(77)90246-7.
7
The relevance of arguments for excluding ALAD from the recommended biological limit values in occupational exposure to inorganic lead (WHO 1980).关于将δ-氨基-γ-酮戊酸脱水酶排除在职业性接触无机铅的推荐生物限值之外的论据的相关性（世界卫生组织，1980年）
Int Arch Occup Environ Health. 1982;50(4):397-412. doi: 10.1007/BF00377836.
8
The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead.职业性铅暴露人群中选定的维生素D受体、血色素沉着症基因和δ-氨基-γ-酮戊酸脱水酶基因多态性与若干基本毒理学参数之间的关系。
Toxicology. 2015 Aug 6;334:12-21. doi: 10.1016/j.tox.2015.05.002. Epub 2015 May 8.
9
ALAD porphyria.
Semin Liver Dis. 1998;18(1):95-101. doi: 10.1055/s-2007-1007145.
引用本文的文献
1
Porphyria: What Is It and Who Should Be Evaluated?卟啉病：它是什么以及谁需要接受评估？
Rambam Maimonides Med J. 2018 Apr 19;9(2):e0013. doi: 10.5041/RMMJ.10333.
2
Peripheral neuropathy in chronic occupational inorganic lead exposure: a clinical and electrophysiological study.慢性职业性无机铅暴露所致周围神经病变：一项临床与电生理研究
J Neurol Neurosurg Psychiatry. 2001 Aug;71(2):200-4. doi: 10.1136/jnnp.71.2.200.
3
Environmental chemical exposures and disturbances of heme synthesis.环境化学物质暴露与血红素合成紊乱
Environ Health Perspect. 1997 Feb;105 Suppl 1(Suppl 1):37-53. doi: 10.1289/ehp.97105s137.
本文引用的文献
1
Lead poisoning in inherited delta-aminolevulinic acid dehydratase deficiency.遗传性δ-氨基-γ-酮戊酸脱水酶缺乏所致铅中毒
Int Arch Occup Environ Health. 1984;54(1):55-63. doi: 10.1007/BF00378728.
2
Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level.铅中毒研究。II. 全血中活化与失活的δ-氨基-γ-酮戊酸脱水酶比值与血铅水平的相关性。
Biochem Med. 1973 Aug;8(1):149-59. doi: 10.1016/0006-2944(73)90018-5.
3
delta-Aminolaevulinic acid dehydratase as an index of the presence and severity of lead poisoning in acute and chronic lead exposure.
Ann Clin Biochem. 1986 Sep;23 ( Pt 5):521-8. doi: 10.1177/000456328602300506.
4
In inherited porphyrias, lead intoxication is a toxogenetic disorder.在遗传性卟啉病中，铅中毒是一种中毒性遗传病。
Int J Biochem. 1987;19(8):717-20. doi: 10.1016/0020-711x(87)90086-3.
5
Determination of lead in blood using electrothermal atomisation atomic absorption spectrometry with a L'vov platform and matrix modifier.使用带L'vov平台和基体改进剂的电热原子化原子吸收光谱法测定血液中的铅
Analyst. 1987 Dec;112(12):1701-4. doi: 10.1039/an9871201701.
6
delta-aminolevulinic acid dehydratase in low level lead exposure.低水平铅暴露中的δ-氨基乙酰丙酸脱水酶
Arch Environ Health. 1976 Jul-Aug;31(4):211-5. doi: 10.1080/00039896.1976.10667221.
7
Modified erythrocyte uroporphyrinogen I synthase assay, and its clinical interpretation.改良红细胞尿卟啉原I合酶测定及其临床解读。
Clin Chem. 1978 Oct;24(10):1751-4.
8
New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation.一种新型肝性卟啉病，伴有胆色素原合酶缺陷及间歇性急性临床表现。
Klin Wochenschr. 1979 Oct 15;57(20):1123-7. doi: 10.1007/BF01481493.
Zotero 插件