Division of Endocrinology, Department of Medicine III, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Cell Metab. 2023 Sep 5;35(9):1497-1499. doi: 10.1016/j.cmet.2023.08.004.
Activation of the hypothalamus-pituitary-adrenal gland (HPA) axis confers adaptations to homeostatic perturbations including food scarcity. A comprehensive new study by Douglass et al. disentangled how agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus (ARC) trigger rapid HPA-axis activation in response to fasting, which is mediated by repression of a tonic, inhibitory neuro circuit.
下丘脑-垂体-肾上腺轴（HPA）的激活赋予了机体适应体内平衡紊乱的能力，包括应对食物匮乏。Douglass 等人的一项全面的新研究阐明了弓状核（ARC）中表达刺鼠相关肽（AgRP）的神经元如何通过抑制一个持续的、抑制性神经回路来触发快速的 HPA 轴激活以响应禁食，这一过程介导了快速的 HPA 轴激活。
