Garfield Alastair S, Shah Bhavik P, Burgess Christian R, Li Monica M, Li Chia, Steger Jennifer S, Madara Joseph C, Campbell John N, Kroeger Daniel, Scammell Thomas E, Tannous Bakhos A, Myers Martin G, Andermann Mark L, Krashes Michael J, Lowell Bradford B
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Centre for Integrative Physiology, Hugh Robson Building, University of Edinburgh, Edinburgh, UK.
Nat Neurosci. 2016 Dec;19(12):1628-1635. doi: 10.1038/nn.4392. Epub 2016 Sep 19.
Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid modulation. Specifically, GABAergic projections arising from the ventral compartment of the dorsomedial nucleus of the hypothalamus (vDMH) contribute to the preconsummatory modulation of ARC neurons. In a manner reciprocal to ARC neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH neurons exhibit rapid activation upon availability of food that additionally reflects the relative value of the food. Thus, leptin receptor-expressing GABAergic vDMH neurons form part of the sensory network that relays real-time information about the nature and availability of food to dynamically modulate ARC neuron activity and feeding behavior.
下丘脑弓状核（ARC）的刺鼠相关肽（AgRP）神经元在热量不足时促进稳态进食，但在摄入之前它们会被与食物相关的感觉线索迅速抑制。在这里，我们确定了一条对AgRP神经元具有高度选择性的抑制性传入神经，它是这种快速调节的神经决定因素。具体而言，源自下丘脑背内侧核腹侧区（vDMH）的γ-氨基丁酸能投射有助于对ARC神经元的摄食前调节。与ARC神经元相互作用的是，投射到ARC的表达瘦素受体的γ-氨基丁酸能vDMH神经元在有食物时会迅速激活，这还反映了食物的相对价值。因此，表达瘦素受体的γ-氨基丁酸能vDMH神经元构成了感觉网络的一部分，该网络传递有关食物性质和可获得性的实时信息，以动态调节ARC神经元活动和进食行为。
