Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, Tamil Nadu, India.
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
Int J Biol Macromol. 2023 Dec 31;253(Pt 4):126715. doi: 10.1016/j.ijbiomac.2023.126715. Epub 2023 Sep 5.
For the potential health benefits and nutritional value, polyphenols are one of the secondary metabolites of plants that have received extensive research. It has anti-inflammatory and cytotoxicity-reducing properties in addition to a high antioxidant content. Macromolecular polyphenols and polysaccharides are biologically active natural polymers with antioxidant and anti-inflammatory potential. Arsenic is an ecologically toxic metalloid. Arsenic in drinking water is the most common way people come into contact with this metalloid. While arsenic is known to cause cancer, it is also used to treat acute promyelocytic leukemia (APL). The treatment's effectiveness is hampered by the adverse effects it can cause on the body. Oxidative stress, inflammation, and the inability to regulate cell death cause the most adverse effects. Polyphenols and other macromolecules like polysaccharides act as neuroprotectants by mitigating free radical damage, inhibiting nitric oxide (NO) production, lowering A42 fibril formation, boosting antioxidant levels, and controlling apoptosis and inflammation. To prevent the harmful effects of toxins, polyphenols and pectin lower oxidative stress, boost antioxidant levels, improve mitochondrial function, control apoptosis, and suppress inflammation. Therefore, it prevents damage to the heart, liver, kidneys, and reproductive system. This review aims to identify the effects of the polyphenols in conjugation with polysaccharides as an ameliorative strategy for arsenic-induced toxicity in various organs.
由于具有潜在的健康益处和营养价值，多酚作为植物的次生代谢产物之一，受到了广泛的研究。它除了具有高抗氧化含量外，还具有抗炎和降低细胞毒性的特性。 高分子多酚和多糖是具有抗氧化和抗炎潜力的生物活性天然聚合物。砷是一种生态毒性的类金属。饮用水中的砷是人们接触这种类金属的最常见方式。虽然砷已被证明会致癌，但它也被用于治疗急性早幼粒细胞白血病（APL）。这种治疗方法的有效性受到其对身体造成的不良反应的阻碍。氧化应激、炎症和细胞死亡调节能力的丧失会导致最不利的影响。多酚和其他像多糖这样的高分子通过减轻自由基损伤、抑制一氧化氮（NO）的产生、降低 A42 纤维形成、提高抗氧化剂水平以及控制细胞凋亡和炎症来发挥神经保护作用。为了防止毒素的有害影响，多酚和果胶降低氧化应激、提高抗氧化剂水平、改善线粒体功能、控制细胞凋亡和抑制炎症。因此，它可以预防对心脏、肝脏、肾脏和生殖系统的损害。本综述旨在确定多酚与多糖结合作为一种改善砷诱导的各种器官毒性的策略的效果。
