Qian Yingying, Liu Qiang, Li Tianlang
Department of Geriatrics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Neurol. 2025 Apr 25;16:1529989. doi: 10.3389/fneur.2025.1529989. eCollection 2025.
Antioxidant-rich diets are posited as protective factors against cognitive function impairment. The Composite Dietary Antioxidant Index (CDAI) serves as a pivotal measure of antioxidant intake, yet its relationship with cognitive function impairment has been sparsely investigated. Herein, the purpose of this study was to investigate the relationship between CDAI and cognitive function impairment.
An analysis of data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2014 was conducted to examine the relationship between the CDAI and cognitive function impairment by multivariate logistic regression, and its nonlinearity was verified by restricted cubic spline (RCS) regression. Moreover, a risk prediction nomogram model containing the key factors determined by logistic regression methods was constructed to estimate the probability of cognitive function impairment in older adults.
Compared with participants with normal cognitive performance, those with low cognitive performance were likely to have higher age, lower education, lower household income, and lower CDAI score. In a multivariate logistic regression model adjusted for confounding variables, the CDAI score was associated with the CERAD word learning subtest was still significant, the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) was 0.94 (0.90,0.98), while the association with AFT and DSST was not statistically significant. The RCS curves indicate that there was a smooth L-shaped correlation between CDAI index and cognitive performance. Moreover, the nomogram model based on the key factors determined by logistic regression has a good predictive value for cognitive function impairment (AUC = 0.747, 95%CI:0.726-0.768).
Our study determined a nonlinear and negative association between CDAI and cognitive function impairment in the US elderly population. And a risk prediction nomogram model was constructed to estimate the probability of cognitive function impairment in older adults.
富含抗氧化剂的饮食被认为是预防认知功能障碍的保护因素。复合膳食抗氧化指数（CDAI）是抗氧化剂摄入量的关键衡量指标，但其与认知功能障碍的关系鲜有研究。本研究旨在探讨CDAI与认知功能障碍之间的关系。
对2011年至2014年美国国家健康与营养检查调查（NHANES）的数据进行分析，通过多因素逻辑回归研究CDAI与认知功能障碍之间的关系，并采用受限立方样条（RCS）回归验证其非线性关系。此外，构建了一个包含通过逻辑回归方法确定的关键因素的风险预测列线图模型，以估计老年人认知功能障碍的概率。
与认知表现正常的参与者相比，认知表现较差的参与者年龄可能更大、教育程度更低、家庭收入更低且CDAI得分更低。在调整混杂变量的多因素逻辑回归模型中，CDAI得分与CERAD单词学习子测试相关仍具有统计学意义，调整后的比值比（OR）及其95%置信区间（CI）为0.94（0.90，0.98），而与AFT和DSST的关联无统计学意义。RCS曲线表明，CDAI指数与认知表现之间存在平滑的L形相关性。此外，基于逻辑回归确定的关键因素构建的列线图模型对认知功能障碍具有良好的预测价值（AUC = 0.747，95%CI：0.726 - 0.768）。
我们的研究确定了美国老年人群中CDAI与认知功能障碍之间存在非线性负相关关系。并构建了一个风险预测列线图模型来估计老年人认知功能障碍的概率。
