Föhse Konstantin, Geckin Büsra, Zoodsma Martijn, Kilic Gizem, Liu Zhaoli, Röring Rutger J, Overheul Gijs J, van de Maat Josephine, Bulut Ozlem, Hoogerwerf Jacobien J, Ten Oever Jaap, Simonetti Elles, Schaal Heiner, Adams Ortwin, Müller Lisa, Ostermann Philipp Niklas, van de Veerdonk Frank L, Joosten Leo A B, Haagmans Bart L, van Crevel Reinout, van Rij Ronald P, GeurtsvanKessel Corine, de Jonge Marien I, Li Yang, Domínguez-Andrés Jorge, Netea Mihai G
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), A Joint Venture Between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; TWINCORE, A Joint Venture Between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
Clin Immunol. 2023 Oct;255:109762. doi: 10.1016/j.clim.2023.109762. Epub 2023 Sep 6.
The mRNA-based BNT162b2 protects against severe disease and mortality caused by SARS-CoV-2 via induction of specific antibody and T-cell responses. Much less is known about its broad effects on immune responses against other pathogens. Here, we investigated the adaptive immune responses induced by BNT162b2 vaccination against various SARS-CoV-2 variants and its effects on the responsiveness of immune cells upon stimulation with heterologous stimuli. BNT162b2 vaccination induced effective humoral and cellular immunity against SARS-CoV-2 that started to wane after six months. We also observed long-term transcriptional changes in immune cells after vaccination. Additionally, vaccination with BNT162b2 modulated innate immune responses as measured by inflammatory cytokine production after stimulation - higher IL-1/IL-6 release and decreased IFN-α production. Altogether, these data expand our knowledge regarding the overall immunological effects of this new class of vaccines and underline the need for additional studies to elucidate their effects on both innate and adaptive immune responses.
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