Moser Jill, Emous Marloes, Heeringa Peter, Rodenhuis-Zybert Izabela A
Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Center Obesity Northern Netherlands (CON), Department of Surgery, Medical Center Leeuwarden, Leeuwarden, the Netherlands.
Trends Endocrinol Metab. 2023 Nov;34(11):735-748. doi: 10.1016/j.tem.2023.08.010. Epub 2023 Sep 4.
Obesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipose tissue function, either through direct infection or by indirect mechanisms. Indeed, recent reports have begun to shed some light on the important role that the adipose tissue plays during the acute phase of infection, as well as mediating long-term sequelae. In this review, we examine the evidence of extrapulmonary dissemination of SARS-CoV-2 to the adipose tissue. We discuss the mechanisms, acute and long-term implications, and possible management strategies to limit or ameliorate severe disease and long-term metabolic disturbances.
肥胖是重症 COVID-19 的独立危险因素，但对于这种关系背后的机制仍缺乏共识。一个备受关注的假说认为，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）通过直接感染或间接机制破坏脂肪组织功能。事实上，最近的报告已开始揭示脂肪组织在感染急性期以及介导长期后遗症中所起的重要作用。在这篇综述中，我们研究了 SARS-CoV-2 向脂肪组织肺外播散的证据。我们讨论了其机制、急性和长期影响，以及限制或改善重症疾病和长期代谢紊乱的可能管理策略。
